Combined use of an epidural cooling catheter and systemic moderate hypothermia enhances spinal cord protection against ischemic injury in rabbits

Shinya Inoue, Atsuo Mori, Hideyuki Shimizu, Akihiro Yoshitake, Ryoichi Tashiro, Nobuyuki Kabei, Ryohei Yozu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Epidural placement of a cooling catheter can protect against ischemic spinal cord injury. With the use of rabbits, we investigated whether this epidural cooling technique, when combined with systemic moderate hypothermia, can protect the spinal cord against ischemic metabolic stress. Methods: New Zealand white rabbits (n = 28) were assigned to 1 of 4 different groups. Animals underwent abdominal aortic occlusion for 30 minutes using a 3F balloon catheter. Group 1 (n = 7) underwent epidural cooling by the catheter and systemic moderate hypothermia (35 C) induced with a cooling blanket. Group 2 (n = 7) underwent epidural cooling under systemic normothermia (38.5 C). Group 3 (n = 7) underwent systemic moderate hypothermia (35 C) without epidural cooling. Group 4 (n = 7) underwent neither epidural nor blanket cooling as a negative control. Neurologic status of their hind limbs was graded according to the modified Tarlov scale at 1, 2, and 7 days after surgery. Results: During infrarenal aortic ischemia, epidural temperature was significantly lower in group 1 (18.5 C ± 0.8 C) than in group 2 (28.6 C ± 1.0 C; P =.0001), group 3 (34.2 C ± 0.06 C; P =.0001), or group 4 (38.5 C ± 0.2 C; P =.0001). Hind limb function recovery was greater in group 1 (mean Tarlov score, 4.9 ± 0.057) than in group 2 (2.6 ± 0.3; P =.0028), group 3 (2.1 ± 0.34; P =.0088), or group 4 (0.0 ± 0.0; P =.0003). Conclusions: Epidural cooling catheter combined with systemic moderate hypothermia produced additive cooling ability and protected the spinal cord against ischemia in rabbits more effectively than either intervention alone.

Original languageEnglish
Pages (from-to)696-701
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume146
Issue number3
DOIs
Publication statusPublished - 2013 Sep
Externally publishedYes

Keywords

  • TAA
  • thoracoabdominal aortic aneurysm

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Combined use of an epidural cooling catheter and systemic moderate hypothermia enhances spinal cord protection against ischemic injury in rabbits. / Inoue, Shinya; Mori, Atsuo; Shimizu, Hideyuki; Yoshitake, Akihiro; Tashiro, Ryoichi; Kabei, Nobuyuki; Yozu, Ryohei.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 146, No. 3, 09.2013, p. 696-701.

Research output: Contribution to journalArticle

Inoue, Shinya ; Mori, Atsuo ; Shimizu, Hideyuki ; Yoshitake, Akihiro ; Tashiro, Ryoichi ; Kabei, Nobuyuki ; Yozu, Ryohei. / Combined use of an epidural cooling catheter and systemic moderate hypothermia enhances spinal cord protection against ischemic injury in rabbits. In: Journal of Thoracic and Cardiovascular Surgery. 2013 ; Vol. 146, No. 3. pp. 696-701.
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abstract = "Background: Epidural placement of a cooling catheter can protect against ischemic spinal cord injury. With the use of rabbits, we investigated whether this epidural cooling technique, when combined with systemic moderate hypothermia, can protect the spinal cord against ischemic metabolic stress. Methods: New Zealand white rabbits (n = 28) were assigned to 1 of 4 different groups. Animals underwent abdominal aortic occlusion for 30 minutes using a 3F balloon catheter. Group 1 (n = 7) underwent epidural cooling by the catheter and systemic moderate hypothermia (35 C) induced with a cooling blanket. Group 2 (n = 7) underwent epidural cooling under systemic normothermia (38.5 C). Group 3 (n = 7) underwent systemic moderate hypothermia (35 C) without epidural cooling. Group 4 (n = 7) underwent neither epidural nor blanket cooling as a negative control. Neurologic status of their hind limbs was graded according to the modified Tarlov scale at 1, 2, and 7 days after surgery. Results: During infrarenal aortic ischemia, epidural temperature was significantly lower in group 1 (18.5 C ± 0.8 C) than in group 2 (28.6 C ± 1.0 C; P =.0001), group 3 (34.2 C ± 0.06 C; P =.0001), or group 4 (38.5 C ± 0.2 C; P =.0001). Hind limb function recovery was greater in group 1 (mean Tarlov score, 4.9 ± 0.057) than in group 2 (2.6 ± 0.3; P =.0028), group 3 (2.1 ± 0.34; P =.0088), or group 4 (0.0 ± 0.0; P =.0003). Conclusions: Epidural cooling catheter combined with systemic moderate hypothermia produced additive cooling ability and protected the spinal cord against ischemia in rabbits more effectively than either intervention alone.",
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AU - Inoue, Shinya

AU - Mori, Atsuo

AU - Shimizu, Hideyuki

AU - Yoshitake, Akihiro

AU - Tashiro, Ryoichi

AU - Kabei, Nobuyuki

AU - Yozu, Ryohei

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AB - Background: Epidural placement of a cooling catheter can protect against ischemic spinal cord injury. With the use of rabbits, we investigated whether this epidural cooling technique, when combined with systemic moderate hypothermia, can protect the spinal cord against ischemic metabolic stress. Methods: New Zealand white rabbits (n = 28) were assigned to 1 of 4 different groups. Animals underwent abdominal aortic occlusion for 30 minutes using a 3F balloon catheter. Group 1 (n = 7) underwent epidural cooling by the catheter and systemic moderate hypothermia (35 C) induced with a cooling blanket. Group 2 (n = 7) underwent epidural cooling under systemic normothermia (38.5 C). Group 3 (n = 7) underwent systemic moderate hypothermia (35 C) without epidural cooling. Group 4 (n = 7) underwent neither epidural nor blanket cooling as a negative control. Neurologic status of their hind limbs was graded according to the modified Tarlov scale at 1, 2, and 7 days after surgery. Results: During infrarenal aortic ischemia, epidural temperature was significantly lower in group 1 (18.5 C ± 0.8 C) than in group 2 (28.6 C ± 1.0 C; P =.0001), group 3 (34.2 C ± 0.06 C; P =.0001), or group 4 (38.5 C ± 0.2 C; P =.0001). Hind limb function recovery was greater in group 1 (mean Tarlov score, 4.9 ± 0.057) than in group 2 (2.6 ± 0.3; P =.0028), group 3 (2.1 ± 0.34; P =.0088), or group 4 (0.0 ± 0.0; P =.0003). Conclusions: Epidural cooling catheter combined with systemic moderate hypothermia produced additive cooling ability and protected the spinal cord against ischemia in rabbits more effectively than either intervention alone.

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