Construction of HIV Rev peptides containing peptide nucleic acid that bind HIV RRE IIB RNA

Ichiro Kumagai, Tsuyoshi Takahashi, Keita Hamasaki, Akihiko Ueno, Hisakazu Mihara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Peptides containing peptide nucleic acid (PNA) have been designed and synthesized to construct molecules recognizing a bulge or a loop structure of RNA. Such peptides were here designed from the HIV Rev protein that can bind the stem-loop IIB of the Rev responsive element (RRE) RNA. Variations of PNA modulated the binding affinities of the peptides to RRE IIB RNA. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)377-379
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number4
DOIs
Publication statusPublished - 2000 Feb 21
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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