Contradictory responses in induction of delayed type hypersensitivity in orally immunized mice

S. Tsuru, H. Fujisawa, S. Aiso, Y. Zinnaka, K. Nomoto

Research output: Contribution to journalArticle


Induction of delayed type hypersensitivity (DTH) in mice fed with sheep red blood cells (SRBC) and live Vibrio cholerae (V. cholerae) both forcedly and ad lib was comparatively investigated. Although suppression of DTH to SRBC or V. cholerae was induced in mice fed forcedly for 1 or 2 weeks, mice fed ad lib could produce the positive footpad reactions to antigens. Furthermore, the suppression of DTH in forcedly fed mice showed an antigenic specificity. These observations indicated that the induction of unresponsiveness to DTH in orally immunized mice was markedly influenced by the oral administration.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalJournal of Clinical and Laboratory Immunology
Issue number2
Publication statusPublished - 1987 Sep 24


ASJC Scopus subject areas

  • Immunology

Cite this