Correlation of within-individual fluctuation of depressed mood with prefrontal cortex activity during verbal working memory task: Optical topography study

Hiroki Sato, Ryuta Aoki, Takusige Katura, Ryoichi Matsuda, Hideaki Koizumi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Previous studies showed that interindividual variations in mood state are associated with prefrontal cortex (PFC) activity. In this study, we focused on the depressed-mood state under natural circumstances and examined the relationship between within-individual changes over time in this mood state and PFC activity.We used optical topography (OT), a functional imaging technique based on near-infrared spectroscopy, to measure PFC activity for each participant in three experimental sessions repeated at 2-week intervals. In each session, the participants completed a self-report questionnaire of mood state and underwent OT measurement while performing verbal and spatial working memory (WM) tasks. The results showed that changes in the depressed-mood score between successive sessions were negatively correlated with those in the left PFC activation for the verbal WM task (P = -0.56, p < 0.05). In contrast, the PFC activation for the spatial WM task did not co-vary with participants' mood changes. We thus demonstrated that PFC activity during a verbal WM task varies depending on the participant's depressed mood state, independent of trait factors. This suggests that using optical topography to measure PFC activity during a verbalWM task can be used as a potential state marker for an individual's depressed mood state.

Original languageEnglish
Article number126007
JournalJournal of biomedical optics
Volume16
Issue number12
DOIs
Publication statusPublished - 2011 Dec 1

Keywords

  • Depressed mood
  • Near-infrared spectroscopy
  • Optical topography
  • Prefrontal cortex
  • Profile of mood states
  • Working memory

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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