Corticotropinreleasing hormone is significantly upregulated in the mouse paraventricular nucleus following a single oral dose of cinnamtannin A2 as an (−)epicatechin tetramer

Yasuyuki Fujii, Kenta Suzuki, Takahiro Adachi, Shu Taira, Naomi Osakabe

Research output: Contribution to journalArticle


Cinnamtannin A2, an (−)epicatechin tetramer, was reported to have potent physiological activity. Cinnamtannin A2 is rarely absorbed from the gastrointestinal tract into the blood and the mechanisms of its beneficial activities are unknown. Cinnamtannin A2 reported to increase sympathetic nervous activity, which was induced by various stressors. In present study, we examined the stress response in the mouse paraventricular nucleus following a single oral dose of cinnamtannin A2 by monitoring mRNA expres sion of corticotropinreleasing hormone (CRH) and cfos using in situ hybridization. Corticotropinreleasing hormone mRNA showed a tendency to increase at 15 min and significantly increased at 60 min following a single oral administration of 100 µg/kg cinnamtannin A2. After a single dose of 10 µg/kg cinnamtannin A2, there was significant upregulation of CRH mRNA at 60 min. These results suggested that cinnamtannin A2 was recognized as a stressor in central nervous system and this may lead to its beneficial effects on circulation and metabolism.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalJournal of Clinical Biochemistry and Nutrition
Issue number4
Publication statusPublished - 2019 Jan 1



  • Cfos
  • Cinnamtannin A2
  • Corticotropinreleasing hormone
  • Hypothalamicpituitary adrenal axis
  • Stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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