Aqueous solutions of some alcohols such as butanol show peculiar temperature dependence of surface tension. Contrary to ordinary liquids or solutions, the surface tension increases with temperature at the range of high liquid temperature. So at the triple-phase point on a heated surface, the thermo-capillary force acts for the liquid to wet the heated surface, so the solutions are sometimes called as "self-wetting liquids". Self-wetting liquids may prohibit the dry-out of a heated surface so that the heat transfer performance would be enhanced. For this reason, applications of self-wetting liquids to heat transfer devices such as heat pipes are actively studied in recent years. However, the heat transfer characteristics of boiling of self-wetting liquids are not fully understood. In the present research, a boiling experiment of butanol aqueous solution was performed on a heated fine wire in order to make clear the fundamental heat transfer characteristics. A heated wire configuration is easy to observe the phenomena and easy to address the fundamental issues of boiling. In the present experiment, nucleate boiling heat transfer were investigated with special attention to critical heat flux (CHF), by changing solution concentration and temperature. Bubbling aspects were observed by high-speed video camera. It is found from the experiment that CHF is generally enhanced 20 to 50 % when compared to the case of pure water. It is also found that at a certain concentration and at a certain liquid temperature, peculiar boiling takes place where very small bubbles are emitted from the heated wire and CHF enhancement becomes very large from 2 to 3 times higher than CHF of pure water. The temperature when the peculiar boiling takes place is close to boiling temperature of the solution. These results suggest the possibility of application of aqueous solution to high-performance cooling devices utilizing micro-scaled channels because generating bubbles are small enough so that the pressure loss of the flow passage is small and heat transfer rate is very large.