Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups

Hiroshi Tsutsumi, Keita Hamasaki, Hisakazu Mihara, Akihiko Ueno

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A designed cyclodextrin-peptide hybrid, which has multiple functional groups on its α-helix peptide backbone, has been synthesized as a catalyst for ester hydrolysis. Kinetic study revealed that the carboxylate group plays a key role in this system. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)741-743
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number8
DOIs
Publication statusPublished - 2000 Apr
Externally publishedYes

Fingerprint

Cyclodextrins
Functional groups
Peptides
Catalysts
Hydrolysis
Esters
Kinetics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups. / Tsutsumi, Hiroshi; Hamasaki, Keita; Mihara, Hisakazu; Ueno, Akihiko.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 8, 04.2000, p. 741-743.

Research output: Contribution to journalArticle

Tsutsumi, Hiroshi ; Hamasaki, Keita ; Mihara, Hisakazu ; Ueno, Akihiko. / Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups. In: Bioorganic and Medicinal Chemistry Letters. 2000 ; Vol. 10, No. 8. pp. 741-743.
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