Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups

Hiroshi Tsutsumi; Keita Hamasaki; Hisakazu Mihara; Akihiko Ueno

doi:10.1016/S0960-894X(00)00090-1

Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups

Hiroshi Tsutsumi, Keita Hamasaki, Hisakazu Mihara, Akihiko Ueno

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A designed cyclodextrin-peptide hybrid, which has multiple functional groups on its α-helix peptide backbone, has been synthesized as a catalyst for ester hydrolysis. Kinetic study revealed that the carboxylate group plays a key role in this system.

Original language	English
Pages (from-to)	741-743
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(00)00090-1
Publication status	Published - 2000 Apr
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups",

abstract = "A designed cyclodextrin-peptide hybrid, which has multiple functional groups on its α-helix peptide backbone, has been synthesized as a catalyst for ester hydrolysis. Kinetic study revealed that the carboxylate group plays a key role in this system.",

author = "Hiroshi Tsutsumi and Keita Hamasaki and Hisakazu Mihara and Akihiko Ueno",

note = "Funding Information: This work was supported in part by The Japan Securities Scholarship Foundation and The Mochida Memorial Foundation for Medical and Pharmaceutical Research.",

year = "2000",

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AU - Tsutsumi, Hiroshi

AU - Hamasaki, Keita

AU - Mihara, Hisakazu

AU - Ueno, Akihiko

N1 - Funding Information: This work was supported in part by The Japan Securities Scholarship Foundation and The Mochida Memorial Foundation for Medical and Pharmaceutical Research.

PY - 2000/4

Y1 - 2000/4

N2 - A designed cyclodextrin-peptide hybrid, which has multiple functional groups on its α-helix peptide backbone, has been synthesized as a catalyst for ester hydrolysis. Kinetic study revealed that the carboxylate group plays a key role in this system.

AB - A designed cyclodextrin-peptide hybrid, which has multiple functional groups on its α-helix peptide backbone, has been synthesized as a catalyst for ester hydrolysis. Kinetic study revealed that the carboxylate group plays a key role in this system.

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DO - 10.1016/S0960-894X(00)00090-1

M3 - Article

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AN - SCOPUS:0034678837

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 8

ER -

Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups

Abstract

ASJC Scopus subject areas

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