Decellularized porcine aortic intima-media as a potential cardiovascular biomaterial

Pingli Wu, Naoko Nakamura, Tsuyoshi Kimura, Kwangwoo Nam, Toshiya Fujisato, Seiichi Funamoto, Tetsuya Higami, Akio Kishida

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVES The aim of this research is to investigate the histological and mechanical properties of decellularized aortic intima-media, a promising cardiovascular biomaterial. METHODS Porcine aortic intima-media was decellularized using two methods: high hydrostatic pressurization (HHP) and sodium dodecyl sulphate (SDS). The histological properties were characterized using haematoxylin and eosin staining and Elastica van Gieson staining. The mechanical properties were evaluated using a tensile strength test. RESULTS The structure of the HHP-treated samples was unchanged histologically, whereas that of the SDS-treated samples appeared structurally loose. Consequently, with regard to the mechanical properties of SDS-decellularized intima-media, elastic modulus and tensile strength were significantly decreased. CONCLUSIONS The decellularization method affected the structure and the mechanical properties of the biomaterial. The HHP-treated sample was structurally and mechanically similar to the untreated control. Its mechanical properties were similar to those of human heart valves and the iliac artery and vein. Our results imply that porcine aortic intima-media that is decellularized with HHP is a potential cardiovascular biomaterial.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalInteractive Cardiovascular and Thoracic Surgery
Volume21
Issue number2
DOIs
Publication statusPublished - 2015 Aug 1
Externally publishedYes

Keywords

  • Cardiovascular biomaterial
  • Decellularized aortic intima-media
  • Mechanical properties
  • Tissue structure

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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