Degradation of chitosan hydrogel dispersed in dilute carboxylic acids by solution plasma and evaluation of anticancer activity of degraded products

Chayanaphat Chokradjaroen, Ratana Rujiravanit, Sewan Theeramunkong, Nagahiro Saito

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chitosan is a polysaccharide that has been extensively studied in the field of biomedicine, especially its water-soluble degraded products called chitooligosaccharides (COS). In this study, COS were produced by the degradation of chitosan hydrogel dispersed in a dilute solution (i.e., 1.55 mM) of various kinds of carboxylic acids using a non-thermal plasma technology called solution plasma (SP). The degradation rates of chitosan were influenced by the type of carboxylic acids, depending on the interaction between chitosan and each carboxylic acid. After SP treatment, the water-soluble degraded products containing COS could be easily separated from the water-insoluble residue of chitosan hydrogel by centrifugation. The production yields of the COS were mostly higher than 55%. Furthermore, the obtained COS products were evaluated for their inhibitory effect as well as their selectivity against human lung cancer cells (H460) and human lung normal cells (MRC-5).

Original languageEnglish
Article number0102B5
JournalJapanese Journal of Applied Physics
Volume57
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

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Carboxylic acids
Chitosan
Hydrogels
carboxylic acids
degradation
Plasmas
Degradation
lungs
evaluation
products
water
polysaccharides
Water
selectivity
cancer
Centrifugation
Beam plasma interactions
Polysaccharides
cells
Cells

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Degradation of chitosan hydrogel dispersed in dilute carboxylic acids by solution plasma and evaluation of anticancer activity of degraded products. / Chokradjaroen, Chayanaphat; Rujiravanit, Ratana; Theeramunkong, Sewan; Saito, Nagahiro.

In: Japanese Journal of Applied Physics, Vol. 57, No. 1, 0102B5, 01.01.2018.

Research output: Contribution to journalArticle

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