Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines

Yoshitomo Suhara, Yoshihisa Hirota, Kimie Nakagawa, Maya Kamao, Naoko Tsugawa, Toshio Okano

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Novel ω-oxygenated vitamin K2 analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in γ-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K2 analogues for the development of new drugs.

Original languageEnglish
Pages (from-to)3108-3117
Number of pages10
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number6
DOIs
Publication statusPublished - 2008 Mar 15
Externally publishedYes

Keywords

  • K acid
  • Menaquinone-4
  • Metabolite
  • Vitamin K
  • ω-Oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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