Design and synthesis of biologically active analogues of vitamin K2

Evaluation of their biological activities with cultured human cell lines

Yoshitomo Suhara, Yoshihisa Hirota, Kimie Nakagawa, Maya Kamao, Naoko Tsugawa, Toshio Okano

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Novel ω-oxygenated vitamin K2 analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in γ-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K2 analogues for the development of new drugs.

Original languageEnglish
Pages (from-to)3108-3117
Number of pages10
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number6
DOIs
Publication statusPublished - 2008 Mar 15
Externally publishedYes

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Vitamin K 2
Bioactivity
Cells
Carboxylation
Apoptosis
Pharmaceutical Preparations

Keywords

  • ω-Oxidation
  • K acid
  • Menaquinone-4
  • Metabolite
  • Vitamin K

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Design and synthesis of biologically active analogues of vitamin K2 : Evaluation of their biological activities with cultured human cell lines. / Suhara, Yoshitomo; Hirota, Yoshihisa; Nakagawa, Kimie; Kamao, Maya; Tsugawa, Naoko; Okano, Toshio.

In: Bioorganic and Medicinal Chemistry, Vol. 16, No. 6, 15.03.2008, p. 3108-3117.

Research output: Contribution to journalArticle

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