An establishment of safe application ware is now the most important problem to generalize the use of hydrogen energy. This paper describes the result of research project performed as one of the NEDO projects during 2003 to 2004. Accident potentials of hydrogen refueling stations were analyzed based on the case research, and we found that the explosive accident brings significant disasters such as fatal accidents. In the next stage, measures against the explosion accidents were studied, and the way to design more effective protective walls was investigated. As for the damage of walls or the building structures by the blast, explosion tests were performed and the response and damage of reinforced concrete construction was observed. Finally, protection against the collisions by recklessly driven or miss-operated vehicles was studied. These results are applicable to realize safe design of hydrogen refueling stations.