Detection of Isotopic Atropisomerism Based on ortho-H/D Discrimination

Kazuya Saito, Shota Miwa, Asumi Iida, Yuuki Fujimoto, Elsa Caytan, Christian Roussel, Osamu Kitagawa

Research output: Contribution to journalArticlepeer-review

Abstract

Racemic and optically active 3-(2-deuteriophenyl)-2-(1-phenylpropan-2-yl)quinazoline-4-thiones were prepared. The nuclear magnetic resonance spectra clearly show that they exist as a 1:1 mixture of diastereomers due to the isotopic atropisomerism based on ortho-H/D discrimination (N-C axial chirality) and a chiral carbon.

Original languageEnglish
Pages (from-to)7492-7496
Number of pages5
JournalOrganic Letters
Volume23
Issue number19
DOIs
Publication statusPublished - 2021 Oct 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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