Abstract
A solution of polyhexamethylene biguanide hydrochloride (PHMB-HCl) was titrated with a standard solution of potassium poly(vinyl sulfate) (PVSK) using crystal violet (CV) as an photometric indicator cation. The end point was detected by a sharp absorbance change due to an abrupt decrease in the concentration of CV. A linear relationship between the concentration of PHMB-HCl and the end-point volume of the titrant existed in the concentration range from 2 to 10 × 10 -6 eq mol L -1. Back-titration was based on adding an excess amount of PVSK to a sample solution containing CV, which was titrated with a standard solution of poly(diallyldimethylammonium chloride) (PDADMAC). The calibration curve of the PHMB-HCl concentration to the end point volume of the titrant was also linear in the concentration range from 2 to 8 × 10 -6 eq mol L -1. Both photometric titrations were applied to the determination of PHMB-HCl in a few contact-lens detergents. Back-titration showed a clear end point, but direct titration showed an unclear end point. The results of the back-titration of PHMB-HCl were compared with the content registered in its labels.
| Original language | English |
|---|---|
| Pages (from-to) | 817-821 |
| Number of pages | 5 |
| Journal | Analytical Sciences |
| Volume | 27 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Analytical Chemistry
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Determination of polyhexamethylene biguanide hydrochloride using photometric colloidal titration with crystal violet as a color indicator. / Masadome, Takashi; Miyanishi, Takaaki; Watanabe, Keita; Ueda, Hiroshi; Hattori, Toshiaki.
In: Analytical Sciences, Vol. 27, No. 8, 2011, p. 817-821.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Determination of polyhexamethylene biguanide hydrochloride using photometric colloidal titration with crystal violet as a color indicator
AU - Masadome, Takashi
AU - Miyanishi, Takaaki
AU - Watanabe, Keita
AU - Ueda, Hiroshi
AU - Hattori, Toshiaki
PY - 2011
Y1 - 2011
N2 - A solution of polyhexamethylene biguanide hydrochloride (PHMB-HCl) was titrated with a standard solution of potassium poly(vinyl sulfate) (PVSK) using crystal violet (CV) as an photometric indicator cation. The end point was detected by a sharp absorbance change due to an abrupt decrease in the concentration of CV. A linear relationship between the concentration of PHMB-HCl and the end-point volume of the titrant existed in the concentration range from 2 to 10 × 10 -6 eq mol L -1. Back-titration was based on adding an excess amount of PVSK to a sample solution containing CV, which was titrated with a standard solution of poly(diallyldimethylammonium chloride) (PDADMAC). The calibration curve of the PHMB-HCl concentration to the end point volume of the titrant was also linear in the concentration range from 2 to 8 × 10 -6 eq mol L -1. Both photometric titrations were applied to the determination of PHMB-HCl in a few contact-lens detergents. Back-titration showed a clear end point, but direct titration showed an unclear end point. The results of the back-titration of PHMB-HCl were compared with the content registered in its labels.
AB - A solution of polyhexamethylene biguanide hydrochloride (PHMB-HCl) was titrated with a standard solution of potassium poly(vinyl sulfate) (PVSK) using crystal violet (CV) as an photometric indicator cation. The end point was detected by a sharp absorbance change due to an abrupt decrease in the concentration of CV. A linear relationship between the concentration of PHMB-HCl and the end-point volume of the titrant existed in the concentration range from 2 to 10 × 10 -6 eq mol L -1. Back-titration was based on adding an excess amount of PVSK to a sample solution containing CV, which was titrated with a standard solution of poly(diallyldimethylammonium chloride) (PDADMAC). The calibration curve of the PHMB-HCl concentration to the end point volume of the titrant was also linear in the concentration range from 2 to 8 × 10 -6 eq mol L -1. Both photometric titrations were applied to the determination of PHMB-HCl in a few contact-lens detergents. Back-titration showed a clear end point, but direct titration showed an unclear end point. The results of the back-titration of PHMB-HCl were compared with the content registered in its labels.
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UR - http://www.scopus.com/inward/citedby.url?scp=80053537739&partnerID=8YFLogxK
U2 - 10.2116/analsci.27.817
DO - 10.2116/analsci.27.817
M3 - Article
C2 - 21828919
AN - SCOPUS:80053537739
VL - 27
SP - 817
EP - 821
JO - Analytical Sciences
JF - Analytical Sciences
SN - 0910-6340
IS - 8
ER -