Determination of polyhexamethylene biguanide hydrochloride using a lactone-rhodamine B-based fluorescence optode

Akane Funaki, Yuta Horikoshi, Teruyuki Kobayashi, Takashi Masadome

Research output: Contribution to journalArticle

Abstract

A new determination method for polyhexamethylene biguanide hydrochloride (PHMB) using a lactone-rhodamine B (L-RB) based fluorescence optode has been developed. The optode membrane consists of 2-nitrophenyl octyl ether as a plasticizer, L-RB, and poly (vinyl chloride). The optode responds to tetrakis (4-fluorophenyl) borate, sodium salt (NaTPBF) in the µM range. The fluorescence intensity of the L-RB film for PHMB solution containing 20 µM NaTPBF decreased linearly as the concentration of the PHMB solution increased in the concentration range from 0 to 8.0 µM, which shows that PHMB with a concentration range of 0 to 8.0 µM is determined by the L-RB film optode. The concentration of PHMB in the contact lens detergents by the proposed method was in accord with its nominal concentration.

Original languageEnglish
Article number262
JournalMolecules
Volume25
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Contact-lens detergent
  • Lactone-rhodamine B
  • Optode
  • Polyhexamethylene biguanide hydrochloride

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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