TY - JOUR
T1 - Development of a microfluidic design for an automatic lab-on-chip operation
AU - Puttaraksa, Nitipon
AU - Whitlow, Harry J.
AU - Napari, Mari
AU - Meriläinen, Leena
AU - Gilbert, Leona
N1 - Funding Information:
This work was partially funded by European union (EU) Grant Agreement Number 262411. The funding source had no involvement or role in the development of this article. Dr. Liping Wang is gratefully acknowledged for conceptualization of the microfluidic design.
Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Simple and easy to use are the keys for developing lab-on-chip technology. Here, a new microfluidic circuit has been designed for an automatic lab-on-chip operation (ALOCO) device. This chip used capillary forces for controlled and precise manipulation of liquids, which were loaded in sequence from different flowing directions towards the analysis area. Using the ALOCO design, a non-expert user is able to operate the chip by pipetting liquids into suitable inlet reservoirs. To test this design, microfluidic devices were fabricated using the programmable proximity aperture lithography technique. The operation of the ALOCO chip was characterized from the flow of red-, blue- and un-dyed deionized water. Experimental result indicated that red water, which filled first the analysis area, was substituted entirely with blue water. Controlled sequential flows of these water in the ALOCO device are demonstrated in this paper.
AB - Simple and easy to use are the keys for developing lab-on-chip technology. Here, a new microfluidic circuit has been designed for an automatic lab-on-chip operation (ALOCO) device. This chip used capillary forces for controlled and precise manipulation of liquids, which were loaded in sequence from different flowing directions towards the analysis area. Using the ALOCO design, a non-expert user is able to operate the chip by pipetting liquids into suitable inlet reservoirs. To test this design, microfluidic devices were fabricated using the programmable proximity aperture lithography technique. The operation of the ALOCO chip was characterized from the flow of red-, blue- and un-dyed deionized water. Experimental result indicated that red water, which filled first the analysis area, was substituted entirely with blue water. Controlled sequential flows of these water in the ALOCO device are demonstrated in this paper.
KW - Capillary flow
KW - Lab-on-chip
KW - MeV ion beam lithography
KW - Microfluidics
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U2 - 10.1007/s10404-016-1808-0
DO - 10.1007/s10404-016-1808-0
M3 - Article
AN - SCOPUS:84989836590
VL - 20
JO - Microfluidics and Nanofluidics
JF - Microfluidics and Nanofluidics
SN - 1613-4982
IS - 10
M1 - 142
ER -