Development of "brain-on-chip" devise including micropump for rapid administration of transmitters by and voltage imaging system for neurosignal detection

K. Harada; Yasuo Yoshimi

Development of "brain-on-chip" devise including micropump for rapid administration of transmitters by and voltage imaging system for neurosignal detection

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We developed a microchip for kinetic analysis of neural response toward chemical stimulation by using rapid electrochemical micropump and realtime voltage imaging. Aplysia neurons stained with a voltage sensitive dye was stimulated by a solution of potassium chloride or acetylcholine administrated by the diaphragm micropump powered by electrolysis. The change in the membrane potential of the neuron was monitored by a fluorescent microscope. The neural response time to acetylcholine was twice as long as that to potassium chloride. The device may be useful for observation of the kinetic effect of therapeutic drugs on neural response to transmitters.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Publisher	Chemical and Biological Microsystems Society
Pages	605-606
Number of pages	2
ISBN (Electronic)	9780979806490
Publication status	Published - 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13

Other

Other	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Country	Ireland
City	Dublin
Period	16/10/9 → 16/10/13

Keywords

Brain-on-chip
Neural signal
Polydimethylsiloxane
Voltage sensitive dye imaging

ASJC Scopus subject areas

Control and Systems Engineering

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Development of "brain-on-chip" devise including micropump for rapid administration of transmitters by and voltage imaging system for neurosignal detection. / Harada, K.; Yoshimi, Yasuo.

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 605-606.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Harada, K & Yoshimi, Y 2016, Development of "brain-on-chip" devise including micropump for rapid administration of transmitters by and voltage imaging system for neurosignal detection. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, pp. 605-606, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 16/10/9.

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