Development of on-chip automatic cell sensing and ejection system

T. Kawahara, T. Mizunuma, H. Uvet, M. Hagiwara, Y. Yamanishi, F. Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We succeeded in automatic dispensing of a single swine oocyte (φ=100 um) from a biochip to atmosphere using developed cell ejection system. The developed system is composed of a cell loader, an inkjet mechanism and a capacitance sensor to dispense a droplet with a single cell. The performance of the sensor and the inkjet were evaluated using the fabricated micro-fluidic chip. We succeeded in sensing the passage of microbeads and oocytes (<|)=50-100 um) with the velocity of over 6 mm/s using a capacitance sensor which was fabricated on a glass substrate by photolithography techniques. The advantages of proposed system were that composed of the reusable drive system and a disposable biochip.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1781-1783
Number of pages3
Volume3
Publication statusPublished - 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen
Duration: 2010 Oct 32010 Oct 7

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CityGroningen
Period10/10/310/10/7

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Keywords

  • Capacitance sensor
  • Cell dispensing
  • Inkjet mechanism
  • Sensor feedback control

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Kawahara, T., Mizunuma, T., Uvet, H., Hagiwara, M., Yamanishi, Y., & Arai, F. (2010). Development of on-chip automatic cell sensing and ejection system. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (Vol. 3, pp. 1781-1783)