Different glial reactions to hippocampal stab wounds in young adult and aged rats

Waner Zhu, Hiroyuki Umegaki, Tadashi Shinkai, Shinobu Kurotani, Yusuke Suzuki, Hidetoshi Endo, Akihisa Iguchi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Brain injury induces reactive gliosis. To examine the activation of glial cells after brain injury in young versus aged rats, we used a brain stab-wound model and examined the expression of cells positive for ED1 (ED1+) and glial fibrillary acidic protein (GFAP+) in the hippocampus in young-mature (3 months) and aged (25 months) Wistar rats at various times following hippocampal stab injury. ED1+ cells appeared more frequently in the aged rats than in the young-mature rats under control conditions, whereas the number of GFAP+ cells was not different between two groups. Following the stab wound, there was an increase in ED1 expression that was delayed but stronger in the aged rats and that persisted longer; the increase of the number of GFAP+ cells also persisted longer. We conclude that different glial reactivity in the aged brain suggests that aging is associated with increased glial responsiveness that may enhance susceptibility to injury and disease in the brain.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number2
Publication statusPublished - 2003 Feb 1
Externally publishedYes

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology


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