DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in an oxygen-saturated aqueous solution

Ikuo Nakanishi, Shunichi Fukuzumi, Toshifumi Konishi, Kei Ohkubo, Mamoru Fujitsuka, Osamu Ito, Naoki Miyata

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The DNA cleavage via superoxide anion, formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in a oxygen-saturated aqueous solution, was discussed. The reorganization energy for the reduction of O2 to O2.- was found to be 43.4 Kcal mol-1. The analysis suggested that the electron transfer from C60.-/γ-CyD to O2 proceeded via an outer sphere pathway.

Original languageEnglish
Pages (from-to)2372-2380
Number of pages9
JournalJournal of Physical Chemistry B
Volume106
Issue number9
DOIs
Publication statusPublished - 2002 Mar 7
Externally publishedYes

Fingerprint

inorganic peroxides
Cyclodextrins
Superoxides
NAD
cleavage
electron transfer
DNA
Negative ions
deoxyribonucleic acid
Oxygen
anions
aqueous solutions
Electrons
oxygen
energy

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in an oxygen-saturated aqueous solution. / Nakanishi, Ikuo; Fukuzumi, Shunichi; Konishi, Toshifumi; Ohkubo, Kei; Fujitsuka, Mamoru; Ito, Osamu; Miyata, Naoki.

In: Journal of Physical Chemistry B, Vol. 106, No. 9, 07.03.2002, p. 2372-2380.

Research output: Contribution to journalArticle

Nakanishi, Ikuo ; Fukuzumi, Shunichi ; Konishi, Toshifumi ; Ohkubo, Kei ; Fujitsuka, Mamoru ; Ito, Osamu ; Miyata, Naoki. / DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in an oxygen-saturated aqueous solution. In: Journal of Physical Chemistry B. 2002 ; Vol. 106, No. 9. pp. 2372-2380.
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