Does vascular endothelial cell or smooth muscle affect the decrease in oxygen consumption of arteriolar wall during vasodilation?

Masahiro Shibata, Tomohiro Komine, Yuki Maeda, Hiroki Nakamura

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Our previous studies demonstrated that vascular wall oxygen consumption rate (QO2) of arteriole under in vivo functional condition was dramatically greater than that reported by isolated vascular segment. Furthermore, such high QO2 of vascular wall decreases during vasodilation. However, it is unknown whether such a reduction in QO2 during vasodilation would be caused by a decrease in consumption of vascular endothelial cell (EC) or smooth muscle. In this study, we aimed to explain whether vascular EC or smooth muscle affects the decrease in vascular wall QO2 during vasodilation. QO2 during EC-dependent and EC-independent vasodilation in rat cremaster muscle was determined using the intra- and peri-vascular PO2 measured by phosphorescence quenching microscopy. EC-dependent vasodilation was induced by increased NO production due to increased blood flow, while EC-independent vasodilation was induced by topical administration of papaverine. EC-dependent and EC-independent vasodilation increased arteriolar diameters by 13% and 17%, respectively, relative to the values under a normal condition. Vascular wall QO2 decreased significantly during both EC-dependent and EC-independent vasodilation as compared with that under a normal condition. Vascular wall QO2 during EC-independent vasodilation was lower than that during EC-dependent vasodilation. However, there was no significant difference between the energy efficiency, which is defined as the variable ratio of circumferential wall tension (amount of mechanical work) to vascular wall QO2 (energy cost) between normal and vasodilated conditions. These results suggest that the decrease in vascular wall QO2 during vasodilation is related to reduced mechanical work of vascular smooth muscle.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages257-261
Number of pages5
DOIs
Publication statusPublished - 2018 Jan 1

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1072
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Endothelial cells
Muscle
Oxygen
Vasodilation
Phosphorescence
Papaverine
Energy efficiency
Rats
Quenching
Microscopic examination
Blood

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Shibata, M., Komine, T., Maeda, Y., & Nakamura, H. (2018). Does vascular endothelial cell or smooth muscle affect the decrease in oxygen consumption of arteriolar wall during vasodilation? In Advances in Experimental Medicine and Biology (pp. 257-261). (Advances in Experimental Medicine and Biology; Vol. 1072). Springer New York LLC. https://doi.org/10.1007/978-3-319-91287-5_41

Does vascular endothelial cell or smooth muscle affect the decrease in oxygen consumption of arteriolar wall during vasodilation? / Shibata, Masahiro; Komine, Tomohiro; Maeda, Yuki; Nakamura, Hiroki.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 257-261 (Advances in Experimental Medicine and Biology; Vol. 1072).

Research output: Chapter in Book/Report/Conference proceedingChapter

Shibata, M, Komine, T, Maeda, Y & Nakamura, H 2018, Does vascular endothelial cell or smooth muscle affect the decrease in oxygen consumption of arteriolar wall during vasodilation? in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1072, Springer New York LLC, pp. 257-261. https://doi.org/10.1007/978-3-319-91287-5_41
Shibata M, Komine T, Maeda Y, Nakamura H. Does vascular endothelial cell or smooth muscle affect the decrease in oxygen consumption of arteriolar wall during vasodilation? In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 257-261. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-91287-5_41
Shibata, Masahiro ; Komine, Tomohiro ; Maeda, Yuki ; Nakamura, Hiroki. / Does vascular endothelial cell or smooth muscle affect the decrease in oxygen consumption of arteriolar wall during vasodilation?. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 257-261 (Advances in Experimental Medicine and Biology).
@inbook{00475c159c7e40c8a491ae6b88413df3,
title = "Does vascular endothelial cell or smooth muscle affect the decrease in oxygen consumption of arteriolar wall during vasodilation?",
abstract = "Our previous studies demonstrated that vascular wall oxygen consumption rate (QO2) of arteriole under in vivo functional condition was dramatically greater than that reported by isolated vascular segment. Furthermore, such high QO2 of vascular wall decreases during vasodilation. However, it is unknown whether such a reduction in QO2 during vasodilation would be caused by a decrease in consumption of vascular endothelial cell (EC) or smooth muscle. In this study, we aimed to explain whether vascular EC or smooth muscle affects the decrease in vascular wall QO2 during vasodilation. QO2 during EC-dependent and EC-independent vasodilation in rat cremaster muscle was determined using the intra- and peri-vascular PO2 measured by phosphorescence quenching microscopy. EC-dependent vasodilation was induced by increased NO production due to increased blood flow, while EC-independent vasodilation was induced by topical administration of papaverine. EC-dependent and EC-independent vasodilation increased arteriolar diameters by 13{\%} and 17{\%}, respectively, relative to the values under a normal condition. Vascular wall QO2 decreased significantly during both EC-dependent and EC-independent vasodilation as compared with that under a normal condition. Vascular wall QO2 during EC-independent vasodilation was lower than that during EC-dependent vasodilation. However, there was no significant difference between the energy efficiency, which is defined as the variable ratio of circumferential wall tension (amount of mechanical work) to vascular wall QO2 (energy cost) between normal and vasodilated conditions. These results suggest that the decrease in vascular wall QO2 during vasodilation is related to reduced mechanical work of vascular smooth muscle.",
author = "Masahiro Shibata and Tomohiro Komine and Yuki Maeda and Hiroki Nakamura",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/978-3-319-91287-5_41",
language = "English",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "257--261",
booktitle = "Advances in Experimental Medicine and Biology",
address = "United States",

}

TY - CHAP

T1 - Does vascular endothelial cell or smooth muscle affect the decrease in oxygen consumption of arteriolar wall during vasodilation?

AU - Shibata, Masahiro

AU - Komine, Tomohiro

AU - Maeda, Yuki

AU - Nakamura, Hiroki

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Our previous studies demonstrated that vascular wall oxygen consumption rate (QO2) of arteriole under in vivo functional condition was dramatically greater than that reported by isolated vascular segment. Furthermore, such high QO2 of vascular wall decreases during vasodilation. However, it is unknown whether such a reduction in QO2 during vasodilation would be caused by a decrease in consumption of vascular endothelial cell (EC) or smooth muscle. In this study, we aimed to explain whether vascular EC or smooth muscle affects the decrease in vascular wall QO2 during vasodilation. QO2 during EC-dependent and EC-independent vasodilation in rat cremaster muscle was determined using the intra- and peri-vascular PO2 measured by phosphorescence quenching microscopy. EC-dependent vasodilation was induced by increased NO production due to increased blood flow, while EC-independent vasodilation was induced by topical administration of papaverine. EC-dependent and EC-independent vasodilation increased arteriolar diameters by 13% and 17%, respectively, relative to the values under a normal condition. Vascular wall QO2 decreased significantly during both EC-dependent and EC-independent vasodilation as compared with that under a normal condition. Vascular wall QO2 during EC-independent vasodilation was lower than that during EC-dependent vasodilation. However, there was no significant difference between the energy efficiency, which is defined as the variable ratio of circumferential wall tension (amount of mechanical work) to vascular wall QO2 (energy cost) between normal and vasodilated conditions. These results suggest that the decrease in vascular wall QO2 during vasodilation is related to reduced mechanical work of vascular smooth muscle.

AB - Our previous studies demonstrated that vascular wall oxygen consumption rate (QO2) of arteriole under in vivo functional condition was dramatically greater than that reported by isolated vascular segment. Furthermore, such high QO2 of vascular wall decreases during vasodilation. However, it is unknown whether such a reduction in QO2 during vasodilation would be caused by a decrease in consumption of vascular endothelial cell (EC) or smooth muscle. In this study, we aimed to explain whether vascular EC or smooth muscle affects the decrease in vascular wall QO2 during vasodilation. QO2 during EC-dependent and EC-independent vasodilation in rat cremaster muscle was determined using the intra- and peri-vascular PO2 measured by phosphorescence quenching microscopy. EC-dependent vasodilation was induced by increased NO production due to increased blood flow, while EC-independent vasodilation was induced by topical administration of papaverine. EC-dependent and EC-independent vasodilation increased arteriolar diameters by 13% and 17%, respectively, relative to the values under a normal condition. Vascular wall QO2 decreased significantly during both EC-dependent and EC-independent vasodilation as compared with that under a normal condition. Vascular wall QO2 during EC-independent vasodilation was lower than that during EC-dependent vasodilation. However, there was no significant difference between the energy efficiency, which is defined as the variable ratio of circumferential wall tension (amount of mechanical work) to vascular wall QO2 (energy cost) between normal and vasodilated conditions. These results suggest that the decrease in vascular wall QO2 during vasodilation is related to reduced mechanical work of vascular smooth muscle.

UR - http://www.scopus.com/inward/record.url?scp=85052881572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052881572&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-91287-5_41

DO - 10.1007/978-3-319-91287-5_41

M3 - Chapter

C2 - 30178355

AN - SCOPUS:85052881572

T3 - Advances in Experimental Medicine and Biology

SP - 257

EP - 261

BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

ER -