Effect of angiotensin II on the proliferation of mammotrophs from the adult rat anterior pituitary in culture

Tadashi Shinkai, Hiroshi Ooka

Research output: Contribution to journalArticle

21 Citations (Scopus)


We measured the influence of prolactin-releasing neuropeptides on mammotroph proliferation in cultures of rat adenohypophysis cells using flow cytometry. Angiotensin II (AII) increased mammotroph proliferation. Other peptides with hormone-releasing activities did not promote growth. Tamoxifen inhibited mammotroph proliferation in control and AII-containing cultures and the inhibition was reversed with β-estradiol. Saralasin, an AII receptor antagonist, suppressed not only AII-induced mammotroph proliferation but also luteinizing hormone-releasing hormone (LHRH)-induced proliferation. These results suggest that hypothalamic LHRH stimulates AII release from gonadotrophs and that AII, with estrogen, controls mammotroph proliferation in rat pituitary.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
Issue number1
Publication statusPublished - 1995
Externally publishedYes



  • Angiotensin II
  • Cell culture
  • Luteinizing hormone-releasing hormone
  • Mammotroph proliferation
  • Rat pituitary

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this