TY - JOUR
T1 - Effect of hyperthermic preconditioning on the survival of ischemia-reperfused skin flaps
T2 - A new skin-flap model in the mouse
AU - Minh, Trinh Cao
AU - Ichioka, Shigeru
AU - Nakatsuka, Takashi
AU - Kawai, Junsuke
AU - Shibata, Masahiro
AU - Ando, Joji
AU - Harii, Kiyonori
PY - 2002/2/18
Y1 - 2002/2/18
N2 - To investigate whether hyperthermic preconditioning can actually protect skin flaps against ischemia/reperfusion injury, the authors first developed a new skin-flap model in 15 mice, a dorsal bipedicle island skin-flap model. Then, another 75 mice were separated into five groups. Mice in Groups 1 to 4 received the same hyperthermic preconditioning, but had different recovery times of 6 hr, 24 hr, 48 hr, and 72 hr, respectively. Mice in Group 5 served as control. Island skin flaps were elevated in all groups, and then were subjected to 8 hr of ischemia and subsequent reperfusion. Flap survival was statistically significantly higher than in controls in animals in Groups 1 and 3, with recovery times of 6 hr and 48 hr, respectively. Mice in Groups 2 and 4 had recovery times of 24 hr and 72 hr, respectively. Hyperthermic preconditioning could thus protect skin flaps against ischemia/reperfusion injury, and there were two optimal periods for such a protective effect.
AB - To investigate whether hyperthermic preconditioning can actually protect skin flaps against ischemia/reperfusion injury, the authors first developed a new skin-flap model in 15 mice, a dorsal bipedicle island skin-flap model. Then, another 75 mice were separated into five groups. Mice in Groups 1 to 4 received the same hyperthermic preconditioning, but had different recovery times of 6 hr, 24 hr, 48 hr, and 72 hr, respectively. Mice in Group 5 served as control. Island skin flaps were elevated in all groups, and then were subjected to 8 hr of ischemia and subsequent reperfusion. Flap survival was statistically significantly higher than in controls in animals in Groups 1 and 3, with recovery times of 6 hr and 48 hr, respectively. Mice in Groups 2 and 4 had recovery times of 24 hr and 72 hr, respectively. Hyperthermic preconditioning could thus protect skin flaps against ischemia/reperfusion injury, and there were two optimal periods for such a protective effect.
KW - Heat shock
KW - Hyperthermic preconditioning
KW - Mouse
KW - Skin flap
UR - http://www.scopus.com/inward/record.url?scp=0036166258&partnerID=8YFLogxK
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U2 - 10.1055/s-2002-19892
DO - 10.1055/s-2002-19892
M3 - Article
C2 - 11823942
AN - SCOPUS:0036166258
VL - 18
SP - 115
EP - 119
JO - Journal of Reconstructive Microsurgery
JF - Journal of Reconstructive Microsurgery
SN - 0743-684X
IS - 2
ER -