Effects of cacao liquor polyphenols on the susceptibility of low-density lipoprotein to oxidation in hypercholesterolemic rabbits.

Naomi Osakabe, M. Natsume, T. Adachi, M. Yamagishi, R. Hirano, T. Takizawa, H. Itakura, K. Kondo

Research output: Contribution to journalArticle

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Abstract

The effects of cacao liquor polyphenols (CLP) on the susceptibility of low-density lipoprotein (LDL) to oxidation in hypercholesterolemic rabbits were examined. Six Japanese white rabbits which had been fed a high cholesterol diet (HCD) for 3 weeks were fed HCD containing 1% CLP for the following 10 days. The susceptibility of LDL to oxidation induced by 2-2'-azobis(4-methoxy-2, 4-dimethylvaleronitrile) (V-70) was evaluated by measuring the production of conjugated dienes and thiobarbituric acid reactive substances (TBARS). The lag time was significantly prolonged from 37.7 min before intake of CLP to 42.9, 44.2 and 45.8 min after 4, 7 and 10 days of CLP intake. TBARS production after intake of CLP was also markedly reduced compared with the level before intake. There was no difference in plasma lipid concentrations comparing the levels before and after CLP intake. In conclusion, in hypercholesterolemic rabbits, orally administered CLP was absorbed and distributed to the blood, and the resistance of LDL to oxidation was thereby increased.

Original languageEnglish
Pages (from-to)164-168
Number of pages5
JournalJournal of Atherosclerosis and Thrombosis
Volume7
Issue number3
Publication statusPublished - 2000
Externally publishedYes

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Polyphenols
LDL Lipoproteins
Oxidation
Thiobarbituric Acid Reactive Substances
Nutrition
Cholesterol
Blood
Lipids
Plasmas

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

Cite this

Effects of cacao liquor polyphenols on the susceptibility of low-density lipoprotein to oxidation in hypercholesterolemic rabbits. / Osakabe, Naomi; Natsume, M.; Adachi, T.; Yamagishi, M.; Hirano, R.; Takizawa, T.; Itakura, H.; Kondo, K.

In: Journal of Atherosclerosis and Thrombosis, Vol. 7, No. 3, 2000, p. 164-168.

Research output: Contribution to journalArticle

Osakabe, N, Natsume, M, Adachi, T, Yamagishi, M, Hirano, R, Takizawa, T, Itakura, H & Kondo, K 2000, 'Effects of cacao liquor polyphenols on the susceptibility of low-density lipoprotein to oxidation in hypercholesterolemic rabbits.', Journal of Atherosclerosis and Thrombosis, vol. 7, no. 3, pp. 164-168.
Osakabe, Naomi ; Natsume, M. ; Adachi, T. ; Yamagishi, M. ; Hirano, R. ; Takizawa, T. ; Itakura, H. ; Kondo, K. / Effects of cacao liquor polyphenols on the susceptibility of low-density lipoprotein to oxidation in hypercholesterolemic rabbits. In: Journal of Atherosclerosis and Thrombosis. 2000 ; Vol. 7, No. 3. pp. 164-168.
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AU - Hirano, R.

AU - Takizawa, T.

AU - Itakura, H.

AU - Kondo, K.

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