Effects of polyphenol substances derived from theobroma cacao on gastric mucosal lesion induced by ethanol

Naomi Osakabe, Chiaki Sanbongi, Megumi Yamagishi, Toshio Takizawa, Toshihiko Osawa

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


The antiulcer activity of cacao liquor water-soluble crude polyphenols (CWSP) was examined. CWSP, α-tocopherol, sucralfate (500 mg/kg), and cimetidine (250 mg/kg) were orally administerted to male SD rats 30 minutes before ethanol treatment. 5 ml/kg of ethanol given intragastrically caused lesions in mucosa of the glandular stomach. CWSP caused a reduction of such hemorrhagic lesions as well as cimetidine and sucralfate which are typical antiulcer drugs, but α-tocopherol was less effective. Thiobarbituric acid reactive substances in gastric mucosa significantly increased with ethanol administration. CWSP treatment significantly reduced this change. The administration of ethanol extensively increased myeloperoxidase (MPO) but not xanthine oxidase (XOD) activity. CWSP reduced the activities of both enzymes; they were considered the main sources of oxygen radicals. According to an in vitro study, CWSP directly reducted XOD but not MPO. These results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function.

Original languageEnglish
Pages (from-to)1535-1538
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number8
Publication statusPublished - 1998
Externally publishedYes


  • Antioxidant
  • Cacao liquor
  • Ethanol
  • Gastric mucosal injury
  • Polyphenols

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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