Effects of Polyphenol Substances Derived from Theobroma cacao on Gastric Mucosal Lesion Induced by Ethanol

Naomi Osakabe, Chiaki Sanbongi, Megumi Yamagishi, Toshio Takizawa, Toshihiko Osawa

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The antiulcer activity of cacao liquor water-soluble crude polyphenols (CWSP) was examined. CWSP, α-tocopherol, sucralfate (500 rag/kg), and cimetidine (250 mg/kg) were orally administered to male SD rats 30 minutes before ethanol treatment. 5 ml/kg of ethanol given intragastrically caused lesions in mucosa of the glandular stomach. CWSP caused a reduction of such hemorrhagic lesions as well as cimetidine and sucralfate which are typical antiulcer drugs, but α-tocopherol was less effective. Thiobarbituric acid reactive substances in gastric mucosa significantly increased with ethanol administration. CWSP treatment significantly reduced this change. The administration of ethanol extensively increased myeloperoxidase (MPO) but not xanthine oxidase (XOD) activity. CWSP reduced the activities of both enzymes; they were considered the main sources of oxygen radicals. According to an in vitro study, CWSP directly reducted XOD but not MPO. These results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function.

Original languageEnglish
Pages (from-to)1535-1538
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume62
Issue number8
Publication statusPublished - 1998 Aug
Externally publishedYes

Fingerprint

chocolate liquor
Theobroma cacao
Polyphenols
lesions (animal)
polyphenols
stomach
Ethanol
ethanol
Water
cimetidine
Sucralfate
water
myeloperoxidase
xanthine oxidase
Tocopherols
Xanthine Oxidase
Cimetidine
tocopherols
Peroxidase
anti-ulcer activity

Keywords

  • Antioxidant
  • Cacao liquor
  • Ethanol
  • Gastric mucosal injury
  • Polyphenols

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Bioengineering

Cite this

Effects of Polyphenol Substances Derived from Theobroma cacao on Gastric Mucosal Lesion Induced by Ethanol. / Osakabe, Naomi; Sanbongi, Chiaki; Yamagishi, Megumi; Takizawa, Toshio; Osawa, Toshihiko.

In: Bioscience, Biotechnology and Biochemistry, Vol. 62, No. 8, 08.1998, p. 1535-1538.

Research output: Contribution to journalArticle

Osakabe, Naomi ; Sanbongi, Chiaki ; Yamagishi, Megumi ; Takizawa, Toshio ; Osawa, Toshihiko. / Effects of Polyphenol Substances Derived from Theobroma cacao on Gastric Mucosal Lesion Induced by Ethanol. In: Bioscience, Biotechnology and Biochemistry. 1998 ; Vol. 62, No. 8. pp. 1535-1538.
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