Efficient synthesis and biological evaluation of ω-oxygenated analogues of vitamin K2

Study of modification and structure-activity relationship of vitamin K2 metabolites

Yoshitomo Suhara, Aya Murakami, Maya Kamao, Shino Mimatsu, Kimie Nakagawa, Naoko Tsugawa, Toshio Okano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Novel ω-oxygenated vitamin K2 analogues, which are candidates for metabolites of vitamin K2 homologues, were efficiently synthesized and their apoptosis-inducing activity was evaluated. We revealed that some of those analogues were biologically active and the side-chain part played an important role in apoptosis-inducing activity. Our results can provide useful information to develop the structure-activity relationship of vitamin K2 analogues for new drugs based on vitamin K.

Original languageEnglish
Pages (from-to)1622-1625
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number6
DOIs
Publication statusPublished - 2007 Mar 15
Externally publishedYes

Fingerprint

Vitamin K 2
Metabolites
Apoptosis
Vitamin K
Pharmaceutical Preparations

Keywords

  • Analogue
  • Apoptosis
  • Menaquinone-4
  • Metabolite
  • Vitamin K

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Efficient synthesis and biological evaluation of ω-oxygenated analogues of vitamin K2 : Study of modification and structure-activity relationship of vitamin K2 metabolites. / Suhara, Yoshitomo; Murakami, Aya; Kamao, Maya; Mimatsu, Shino; Nakagawa, Kimie; Tsugawa, Naoko; Okano, Toshio.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 6, 15.03.2007, p. 1622-1625.

Research output: Contribution to journalArticle

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AU - Tsugawa, Naoko

AU - Okano, Toshio

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