Electron transfer mediated biosensor with plasma-polymerized film containing redox site

Hitoshi Muguruma, Hideyuki Uehara

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


An electron transfer mediated amperometric enzyme biosensor based on a plasma-polymerized thin film of dimethylaminomethylferrocene (DMAMFc) is reported. A nanoscale thin polymer film containing a redox mediator was plasma-deposited directly onto an electrode with physisorbed glucose oxidase (GOD). Since the redox sites were introduced in the vicinity of the reaction centers of GOD, a highly efficient electron transfer system was formed in which almost all the reaction centers of GOD were connected to redox sites of the polymer matrix. The advantages of this strategy were: no need for prior or further chemical modification of the enzyme molecules, and simplicity of design compared with the use of a conventional polymer matrix. Moreover, the fact that the film deposition was performed using a microfabrication-compatible organic plasma promised great potential for high-throughput production of bioelectronic devices.

Original languageEnglish
Pages (from-to)1781-1785
Number of pages5
JournalIEICE Transactions on Electronics
Issue number12
Publication statusPublished - 2006 Dec
Externally publishedYes


  • Electron transfer mediator
  • Enzyme
  • Ferrocene
  • Glucose biosensor
  • Plasma polymerization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering


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