Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex

Tadashi Inoue, Osamu Kitagawa, Shigeyuki Kurumizawa, Orie Ochiai, Takeo Taguchi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The iodocarbocyclization of4-pentenylmalonate derivatives1 proceeded with moderate to high enantiomeric excesses (up to 85 %ee) by treating1 with I2 and CuO in the presence of the chiral titanium alkoxide2. The present reaction should serve as a new method for enantioselective construction of functionalized cyclopentane derivatives.

Original languageEnglish
Pages (from-to)1479-1482
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number9
DOIs
Publication statusPublished - 1995 Feb 27
Externally publishedYes

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Cyclopentanes
Titanium
Derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex. / Inoue, Tadashi; Kitagawa, Osamu; Kurumizawa, Shigeyuki; Ochiai, Orie; Taguchi, Takeo.

In: Tetrahedron Letters, Vol. 36, No. 9, 27.02.1995, p. 1479-1482.

Research output: Contribution to journalArticle

Inoue, Tadashi ; Kitagawa, Osamu ; Kurumizawa, Shigeyuki ; Ochiai, Orie ; Taguchi, Takeo. / Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex. In: Tetrahedron Letters. 1995 ; Vol. 36, No. 9. pp. 1479-1482.
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