Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex

Tadashi Inoue, Osamu Kitagawa, Shigeyuki Kurumizawa, Orie Ochiai, Takeo Taguchi

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Abstract

The iodocarbocyclization of4-pentenylmalonate derivatives1 proceeded with moderate to high enantiomeric excesses (up to 85 %ee) by treating1 with I2 and CuO in the presence of the chiral titanium alkoxide2. The present reaction should serve as a new method for enantioselective construction of functionalized cyclopentane derivatives.

Original languageEnglish
Pages (from-to)1479-1482
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number9
DOIs
Publication statusPublished - 1995 Feb 27

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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