Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex

Tadashi Inoue; Osamu Kitagawa; Shigeyuki Kurumizawa; Orie Ochiai; Takeo Taguchi

doi:10.1016/0040-4039(95)00064-J

Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex

Tadashi Inoue, Osamu Kitagawa, Shigeyuki Kurumizawa, Orie Ochiai, Takeo Taguchi

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The iodocarbocyclization of4-pentenylmalonate derivatives1 proceeded with moderate to high enantiomeric excesses (up to 85 %ee) by treating1 with I₂ and CuO in the presence of the chiral titanium alkoxide2. The present reaction should serve as a new method for enantioselective construction of functionalized cyclopentane derivatives.

Original language	English
Pages (from-to)	1479-1482
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	9
DOIs	https://doi.org/10.1016/0040-4039(95)00064-J
Publication status	Published - 1995 Feb 27
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex",

abstract = "The iodocarbocyclization of4-pentenylmalonate derivatives1 proceeded with moderate to high enantiomeric excesses (up to 85 %ee) by treating1 with I2 and CuO in the presence of the chiral titanium alkoxide2. The present reaction should serve as a new method for enantioselective construction of functionalized cyclopentane derivatives.",

author = "Tadashi Inoue and Osamu Kitagawa and Shigeyuki Kurumizawa and Orie Ochiai and Takeo Taguchi",

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T1 - Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex

AU - Inoue, Tadashi

AU - Kitagawa, Osamu

AU - Kurumizawa, Shigeyuki

AU - Ochiai, Orie

AU - Taguchi, Takeo

PY - 1995/2/27

Y1 - 1995/2/27

N2 - The iodocarbocyclization of4-pentenylmalonate derivatives1 proceeded with moderate to high enantiomeric excesses (up to 85 %ee) by treating1 with I2 and CuO in the presence of the chiral titanium alkoxide2. The present reaction should serve as a new method for enantioselective construction of functionalized cyclopentane derivatives.

AB - The iodocarbocyclization of4-pentenylmalonate derivatives1 proceeded with moderate to high enantiomeric excesses (up to 85 %ee) by treating1 with I2 and CuO in the presence of the chiral titanium alkoxide2. The present reaction should serve as a new method for enantioselective construction of functionalized cyclopentane derivatives.

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U2 - 10.1016/0040-4039(95)00064-J

DO - 10.1016/0040-4039(95)00064-J

M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 9

ER -

Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex

Abstract

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