Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex

Tadashi Inoue; Osamu Kitagawa; Shigeyuki Kurumizawa; Orie Ochiai; Takeo Taguchi

doi:10.1016/0040-4039(95)00064-J

Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex

Tadashi Inoue, Osamu Kitagawa, Shigeyuki Kurumizawa, Orie Ochiai, Takeo Taguchi

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26 Citations (Scopus)

Abstract

The iodocarbocyclization of4-pentenylmalonate derivatives1 proceeded with moderate to high enantiomeric excesses (up to 85 %ee) by treating1 with I₂ and CuO in the presence of the chiral titanium alkoxide2. The present reaction should serve as a new method for enantioselective construction of functionalized cyclopentane derivatives.

Original language	English
Pages (from-to)	1479-1482
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	9
DOIs	https://doi.org/10.1016/0040-4039(95)00064-J
Publication status	Published - 1995 Feb 27

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ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Inoue, T., Kitagawa, O., Kurumizawa, S., Ochiai, O., & Taguchi, T. (1995). Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex. Tetrahedron Letters, 36(9), 1479-1482. https://doi.org/10.1016/0040-4039(95)00064-J

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AU - Ochiai, Orie

AU - Taguchi, Takeo

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10.1016/0040-4039(95)00064-J