Abstract
The iodocarbocyclization of4-pentenylmalonate derivatives1 proceeded with moderate to high enantiomeric excesses (up to 85 %ee) by treating1 with I2 and CuO in the presence of the chiral titanium alkoxide2. The present reaction should serve as a new method for enantioselective construction of functionalized cyclopentane derivatives.
| Original language | English |
|---|---|
| Pages (from-to) | 1479-1482 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 36 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1995 Feb 27 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Inoue, T., Kitagawa, O., Kurumizawa, S., Ochiai, O., & Taguchi, T. (1995). Enantioselective iodocarbocyclization of 4-alkenylmalonate derivatives using a chiral titanium complex. Tetrahedron Letters, 36(9), 1479-1482. https://doi.org/10.1016/0040-4039(95)00064-J