Energetics in arterioles during nitric oxide dependent and independent vasodilation

Masahiro Shibata, Takehiro Yamakoshi, Ken Ichi Yamakoshi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The objective of this study was to evaluate whether the nitric oxide (NO) would decrease vessel wall oxygen consumption by decreasing the mechanical work of vascular smooth muscle. The oxygen consumption rate (QO2) of arteriolar walls in rat cremaster muscle was determined in vivo during NO dependent and -independent vasodilation based on the intra- and perivascular oxygen tension (PO2) measured by phosphorescence quenching technique. NO dependent vasodilation was induced by increased NO production due to increased blood flow, while NO independent vasodilation was induced by topical administration of papaverine. The energy efficiency was evaluated by the variable ratio of wall tension to QO2 between normal and vasodilated conditions. NO dependent and -independent dilation increased arteriolar diameters by 13% and 17%, respectively. Vascular wall QO2 decreased significantly during both dilations. There was no significant difference between the energy efficiency during NO dependent and -independent vasodilation, suggesting the decrease in vascular wall QO2 produced by NO to be related to a decrease in the mechanical work of vascular smooth muscle.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages1695-1698
Number of pages4
DOIs
Publication statusPublished - 2007
Externally publishedYes
Event29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 - Lyon
Duration: 2007 Aug 232007 Aug 26

Other

Other29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
CityLyon
Period07/8/2307/8/26

Fingerprint

Nitric oxide
Muscle
Oxygen
Energy efficiency
Phosphorescence
Vasodilation
Rats
Quenching
Blood

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Shibata, M., Yamakoshi, T., & Yamakoshi, K. I. (2007). Energetics in arterioles during nitric oxide dependent and independent vasodilation. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 1695-1698). [4352635] https://doi.org/10.1109/IEMBS.2007.4352635

Energetics in arterioles during nitric oxide dependent and independent vasodilation. / Shibata, Masahiro; Yamakoshi, Takehiro; Yamakoshi, Ken Ichi.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. p. 1695-1698 4352635.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shibata, M, Yamakoshi, T & Yamakoshi, KI 2007, Energetics in arterioles during nitric oxide dependent and independent vasodilation. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4352635, pp. 1695-1698, 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07, Lyon, 07/8/23. https://doi.org/10.1109/IEMBS.2007.4352635
Shibata M, Yamakoshi T, Yamakoshi KI. Energetics in arterioles during nitric oxide dependent and independent vasodilation. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. p. 1695-1698. 4352635 https://doi.org/10.1109/IEMBS.2007.4352635
Shibata, Masahiro ; Yamakoshi, Takehiro ; Yamakoshi, Ken Ichi. / Energetics in arterioles during nitric oxide dependent and independent vasodilation. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. pp. 1695-1698
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