Epidemiological analysis of the association between hearing and barium in humans

Nobutaka Ohgami, Yuji Mitsumatsu, Nazmul Ahsan, Anwarul Azim Akhand, Xiang Li, MacHiko Iida, Ichiro Yajima, Mariko Naito, Kenji Wakai, Shoko Ohnuma, Masashi Kato

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Our previous study experimentally showed barium (Ba)-mediated hearing loss in mice. To our knowledge, however, it remains unknown whether Ba affects hearing in humans. This epidemiological study aimed at investigating ototoxicity of Ba in humans. Associations of Ba levels in hair, toenails and urine with hearing levels (1, 4, 8 and 12 kHz) were analyzed in 145 Bangladeshi subjects. Binary logistic regression analysis with adjustment for age, sex, body mass index (BMI) and smoking showed that Ba levels in hair had significant associations with hearing loss at 8 kHz (OR=4.75; 95% CI: 1.44, 17.68) and 12 kHz (OR=15.48; 95% CI: 4.04, 79.45). Ba levels in toenails were also associated with hearing loss at 8 kHz (OR=3.20; 95% CI: 1.35, 7.85) and 12 kHz (OR=3.63; 95% CI: 1.58, 8.55), whereas there was no correlation between Ba level in urinary samples and hearing. There was a significant correlation between hearing loss and Ba levels in hair and toenails in the model adjusted with arsenic levels as the confounder. In conclusion, this study suggested that Ba levels could be a new risk factor for hearing loss, especially at high frequencies of 8 and 12 kHz, in humans.

Original languageEnglish
Pages (from-to)488-493
Number of pages6
JournalJournal of Exposure Science and Environmental Epidemiology
Volume26
Issue number5
DOIs
Publication statusPublished - 2016 Sep 1
Externally publishedYes

Fingerprint

Audition
Barium
Arsenic
Regression analysis
Logistics

Keywords

  • Barium
  • Hair
  • Hearing loss
  • ICP-MS
  • Ototoxicity
  • Toenail

ASJC Scopus subject areas

  • Epidemiology
  • Toxicology
  • Pollution
  • Public Health, Environmental and Occupational Health

Cite this

Epidemiological analysis of the association between hearing and barium in humans. / Ohgami, Nobutaka; Mitsumatsu, Yuji; Ahsan, Nazmul; Akhand, Anwarul Azim; Li, Xiang; Iida, MacHiko; Yajima, Ichiro; Naito, Mariko; Wakai, Kenji; Ohnuma, Shoko; Kato, Masashi.

In: Journal of Exposure Science and Environmental Epidemiology, Vol. 26, No. 5, 01.09.2016, p. 488-493.

Research output: Contribution to journalArticle

Ohgami, N, Mitsumatsu, Y, Ahsan, N, Akhand, AA, Li, X, Iida, M, Yajima, I, Naito, M, Wakai, K, Ohnuma, S & Kato, M 2016, 'Epidemiological analysis of the association between hearing and barium in humans', Journal of Exposure Science and Environmental Epidemiology, vol. 26, no. 5, pp. 488-493. https://doi.org/10.1038/jes.2015.62
Ohgami, Nobutaka ; Mitsumatsu, Yuji ; Ahsan, Nazmul ; Akhand, Anwarul Azim ; Li, Xiang ; Iida, MacHiko ; Yajima, Ichiro ; Naito, Mariko ; Wakai, Kenji ; Ohnuma, Shoko ; Kato, Masashi. / Epidemiological analysis of the association between hearing and barium in humans. In: Journal of Exposure Science and Environmental Epidemiology. 2016 ; Vol. 26, No. 5. pp. 488-493.
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