Evaluation of Pulsatile and Nonpulsatile Flow in Microvessels of the Bulbar Conjunctiva in the Goat with an Undulation Pump Artificial Heart

Atsushi Baba; Petr Dobsak; Shuichi Mochizuki; Itsuro Saito; Takashi Isoyama; Koki Takiura; Masahiro Shibata; Yusuke Abe; Tsuneo Chinzei; Jaromir Vasku; Kou Imachi

doi:10.1046/j.1525-1594.2003.00027.x

Evaluation of Pulsatile and Nonpulsatile Flow in Microvessels of the Bulbar Conjunctiva in the Goat with an Undulation Pump Artificial Heart

Atsushi Baba, Petr Dobsak, Shuichi Mochizuki, Itsuro Saito, Takashi Isoyama, Koki Takiura, Masahiro Shibata, Yusuke Abe, Tsuneo Chinzei, Jaromir Vasku, Kou Imachi

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

This study has three purposes, as follows. The first is to develop a microscopic system to observe the microcirculation of animals implanted with an artificial heart. The second is to investigate the influence of flow pattern change from pulsatile to nonpulsatile on the microcirculation. The third is to study the effects of pulsatility in blood flow on endothelium-derived nitric oxide release in the microvasculature. When the flow pattern was changed from pulsatile to nonpulsatile, the velocity of erythrocytes in many capillaries dropped and remained at a low level, and the number of perfused capillaries decreased. After the flow pattern was returned to pulsatile, the velocity of erythrocytes recovered to the initial level. In many cases, the flow of nonperfused capillaries recovered to the initial level as well. Also, the pulsatile flow enhances the basal and flow-stimulated endothelium-derived nitric oxide release in microvessels.

Original language	English
Pages (from-to)	875-881
Number of pages	7
Journal	Artificial Organs
Volume	27
Issue number	10
DOIs	https://doi.org/10.1046/j.1525-1594.2003.00027.x
Publication status	Published - 2003 Oct

Keywords

Artificial heart
Bulbar conjunctiva
Endothelium-derived nitric oxide
Microcirculation
Nonpulsatile flow
Pulsatile flow

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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Evaluation of Pulsatile and Nonpulsatile Flow in Microvessels of the Bulbar Conjunctiva in the Goat with an Undulation Pump Artificial Heart. / Baba, Atsushi; Dobsak, Petr; Mochizuki, Shuichi; Saito, Itsuro; Isoyama, Takashi; Takiura, Koki; Shibata, Masahiro; Abe, Yusuke; Chinzei, Tsuneo; Vasku, Jaromir; Imachi, Kou.

In: Artificial Organs, Vol. 27, No. 10, 10.2003, p. 875-881.

Research output: Contribution to journal › Article › peer-review

Baba, Atsushi ; Dobsak, Petr ; Mochizuki, Shuichi ; Saito, Itsuro ; Isoyama, Takashi ; Takiura, Koki ; Shibata, Masahiro ; Abe, Yusuke ; Chinzei, Tsuneo ; Vasku, Jaromir ; Imachi, Kou. / Evaluation of Pulsatile and Nonpulsatile Flow in Microvessels of the Bulbar Conjunctiva in the Goat with an Undulation Pump Artificial Heart. In: Artificial Organs. 2003 ; Vol. 27, No. 10. pp. 875-881.

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