Evaluation of shear wave dispersion caused by fibrous structure and tissue viscosity using hepatic fibrosis progression and histological models

Shiori Fujii, Makoto Yamakawa, Masatoshi Kudo, Kengo Kondo, Tsuyoshi Shiina, Takeshi Namita

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Shear wave elasticity imaging has been utilized for chronic hepatitis diagnosis. The relationship between hepatic fibrosis and elasticity or viscosity has been described recently. Therefore, it is expected that viscosity analysis will improve the accuracy of staging fibrosis, in addition to elasticity measuring. However, fibrous structures affect dispersion slope analysis, so it is necessary to investigate the effect of fibrous structure on dispersion slope analysis. In order to simulate shear wave propagation in liver tissue, we use two types of models representing fibrosis progression. One is created using a potential function, and the other is created from hepatic histological sections. Simulating shear wave propagation in these models without viscosity in order to examine the effect of fibrous structure alone, dispersion analysis was applied to the particle velocity data. We evaluated the dispersion slope and shear wave phase velocity at 200 Hz (c (200 Hz)). In both models, the dispersion slope increased significantly with fibrosis progression. The resulting dispersion slope is about 30% of the dispersion slope in in vivo measurements, indicating that the effect of fibrous structure is large enough for viscosity analysis.

Original languageEnglish
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
DOIs
Publication statusPublished - 2017 Oct 31
Externally publishedYes
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: 2017 Sep 62017 Sep 9

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2017 IEEE International Ultrasonics Symposium, IUS 2017
Country/TerritoryUnited States
CityWashington
Period17/9/617/9/9

Keywords

  • Chronic hepatitis
  • Liver fibrous structure
  • Shear wave dispersion
  • Shear wave elastography
  • Tissue viscosity

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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