Evaluation of the usefulness of handheld photoacoustic imaging system for quantitative diagnosis of fatty liver

Kyosuke Asada, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)


Quantification fatty liver is useful for early detection of liver disease. Now ultrasonic detection is used for screening fatty liver. But it lacks of quantity and objectivity. Photoacoustic (PA) imaging, a novel modality, is expected for applying to estimate fat rate of liver. To realize estimation of fat rate, we developed handheld PA system using multi wavelengths. In this study, we verified the usefulness of the system for estimate fat rate in ex vivo experiments. As a biological sample, the mixtures of chicken liver, olive oil and lard (the mixing rate of the lipid in the liver is from 0 to 0.3with an interval 0.1) was used. We acquired PA spectra of the sample by developed handheld system. Nanosecond pulses of laser light (800-1300 nm wavelength, 30 Hz repetition rate) were guided to the sample surface by an optical fiber bundle close to the linear ultrasound probe. By analyzing PA spectra, we can find liver have peak PA intensity around 900 nm and lipid have it around 1210 nm where the light absorbance is high. To estimate fat rate using photoacoustic methods, the photoacoustic signal intensity ratio between two wavelength regions was calculated as described above. Signal intensity ratios agreed well with the composition ratio between liver and lipid. From these analyses, the advantage of PA spectra for estimation of fat rate, and the feasibility of our system for early detection of fatty liver were demonstrated. Devising a technique for quantifying fatty liver and in-vivo experiments will be conducted in further studies.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2019
EditorsLihong V. Wang, Alexander A. Oraevsky
ISBN (Electronic)9781510623989
Publication statusPublished - 2019
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2019 - San Francisco, United States
Duration: 2019 Feb 32019 Feb 6

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2019
Country/TerritoryUnited States
CitySan Francisco


  • Hepatic disease
  • Lifestyle disease
  • Multi-wavelength
  • Optoacoustic imaging
  • Photoacoustic spectroscopy
  • Three-dimensional

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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