Abstract
Recent advances in neuro-immunology are beginning to elucidate several essential roles of the humoral immunity in both repair and pathogenesis of central nervous system diseases. Immunoglobulin M (IgM) was reported to accelerate the rate of remyelination in a demyelinating disease model, while intrathecal IgM synthesis was shown to predict a more worse disease course in a human demyelinating disease, multiple sclerosis. Molecular mechanisms for either of these IgM functions remain to be studied. Here we report that a recently-found Fc receptor for IgM, namely Fcα/μR, is expressed in oligodendrocytes, their precursor cells, and myelin. These expressions were confirmed by immunocytochemistry of cultured cells, Western blot analysis of myelin fractions, and also by immunohistochemistry of mouse forebrains at different ages. Our findings suggest a possible direct interaction between IgM and Fcα/μR expressed in oligodendrocytes and myelin.
| Original language | English |
|---|---|
| Pages (from-to) | 73-76 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 337 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2003 Feb 6 |
| Externally published | Yes |
Keywords
- Central nervous system
- Fc receptor
- Fcα/μR
- Immunoglobulin M
- Myelin
- Oligodendrocyte
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Expression of Fc receptor for immunoglobulin M in oligodendrocytes and myelin of mouse central nervous system. / Nakahara, Jin; Seiwa, Chika; Shibuya, Akira; Aiso, Sadakazu; Asou, Hiroaki.
In: Neuroscience Letters, Vol. 337, No. 2, 06.02.2003, p. 73-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of Fc receptor for immunoglobulin M in oligodendrocytes and myelin of mouse central nervous system
AU - Nakahara, Jin
AU - Seiwa, Chika
AU - Shibuya, Akira
AU - Aiso, Sadakazu
AU - Asou, Hiroaki
PY - 2003/2/6
Y1 - 2003/2/6
N2 - Recent advances in neuro-immunology are beginning to elucidate several essential roles of the humoral immunity in both repair and pathogenesis of central nervous system diseases. Immunoglobulin M (IgM) was reported to accelerate the rate of remyelination in a demyelinating disease model, while intrathecal IgM synthesis was shown to predict a more worse disease course in a human demyelinating disease, multiple sclerosis. Molecular mechanisms for either of these IgM functions remain to be studied. Here we report that a recently-found Fc receptor for IgM, namely Fcα/μR, is expressed in oligodendrocytes, their precursor cells, and myelin. These expressions were confirmed by immunocytochemistry of cultured cells, Western blot analysis of myelin fractions, and also by immunohistochemistry of mouse forebrains at different ages. Our findings suggest a possible direct interaction between IgM and Fcα/μR expressed in oligodendrocytes and myelin.
AB - Recent advances in neuro-immunology are beginning to elucidate several essential roles of the humoral immunity in both repair and pathogenesis of central nervous system diseases. Immunoglobulin M (IgM) was reported to accelerate the rate of remyelination in a demyelinating disease model, while intrathecal IgM synthesis was shown to predict a more worse disease course in a human demyelinating disease, multiple sclerosis. Molecular mechanisms for either of these IgM functions remain to be studied. Here we report that a recently-found Fc receptor for IgM, namely Fcα/μR, is expressed in oligodendrocytes, their precursor cells, and myelin. These expressions were confirmed by immunocytochemistry of cultured cells, Western blot analysis of myelin fractions, and also by immunohistochemistry of mouse forebrains at different ages. Our findings suggest a possible direct interaction between IgM and Fcα/μR expressed in oligodendrocytes and myelin.
KW - Central nervous system
KW - Fc receptor
KW - Fcα/μR
KW - Immunoglobulin M
KW - Myelin
KW - Oligodendrocyte
UR - http://www.scopus.com/inward/record.url?scp=0037421507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037421507&partnerID=8YFLogxK
U2 - 10.1016/s0304-3940(02)01312-5
DO - 10.1016/s0304-3940(02)01312-5
M3 - Article
VL - 337
SP - 73
EP - 76
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -