Fc receptor-positive cells in remyelinating multiple sclerosis lesions

Jin Nakahara, Sadakazu Aiso

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The capacity for spontaneous remyelination in cases of multiple sclerosis (MS) is limited and lesions are not fully repaired. Recent evidence has shown that oligodendrocyte precursor cells and immature oligodendrocytes (OPC/iOligs) are preserved in MS lesions. Induced differentiation of these cells into myelinating cells may ultimately lead to a novel remyelination therapy. A previous study showed that the γ chain of immunoglobulin Fc receptors (FcRγ), expressed in OPC/iOligs, is essential for their differentiation. Whether FcRγ is expressed in preserved OPC/iOligs within MS lesions, however, remains uncertain. In the present study, we examined 10 autopsy cases of MS for the expression of FcRγ both in remyelinating areas and demyelinated plaques. The expression of FcRγ was confirmed in both OPC/iOligs and microglia in MS lesions. Statistical analysis showed that the density of FcRγ-positive OPC/iOligs was approximately 3 times greater in remyelinating areas compared with demyelinated plaques; the opposite was true of FcRγ-positive microglia. The distribution of FcRγ-negative OPC/iOligs did not differ between the 2 types of lesions. Thus, an increase in FcRγ-positive OPC/iOligs and a decrease in FcRγ-positive microglia, but not in FcRγ-negative OPC/iOligs, are associated with spontaneous remyelination in MS brains, suggesting a possible role for FcRγ in the induction of remyelination.

Original languageEnglish
Pages (from-to)582-591
Number of pages10
JournalJournal of Neuropathology and Experimental Neurology
Volume65
Issue number6
DOIs
Publication statusPublished - 2006 Jun 1
Externally publishedYes

Keywords

  • Immunoglobulin Fc receptors
  • Multiple sclerosis
  • Oligodendrocyte
  • Remyelination

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Fc receptor-positive cells in remyelinating multiple sclerosis lesions. / Nakahara, Jin; Aiso, Sadakazu.

In: Journal of Neuropathology and Experimental Neurology, Vol. 65, No. 6, 01.06.2006, p. 582-591.

Research output: Contribution to journalArticle

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