Fluorometric biosniffer (biochemical gas sensor) for breath acetone as a volatile indicator of lipid metabolism

Kohji Mitsubayashi, Po Jen Chien, Ming Ye, Takuma Suzuki, Koji Toma, Takahiro Arakawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A fluorometric acetone biosniffer (biochemical gas sensor) for assessment of lipid metabolism utilizing reverse reaction of secondary alcohol dehydrogenase was constructed and evaluated. The biosniffer showed highly sensitivity and selectivity for continuous monitoring of gaseous acetone. The measurement of breath acetone concentration during fasting and aerobic exercise were also investigated. The acetone biosniffer provides a novel analytical tool for noninvasive evaluation of human lipid metabolism and it is also expected to use for the clinical and physiological applications such as monitoring the progression of diabetes.

Original languageEnglish
Title of host publicationSPIE BioPhotonics Australasia
EditorsEwa M. Goldys, Mark R. Hutchinson
PublisherSPIE
ISBN (Electronic)9781510604346
DOIs
Publication statusPublished - 2016
Externally publishedYes
EventSPIE BioPhotonics Australasia - Adelaide, Australia
Duration: 2016 Oct 172016 Oct 19

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume10013
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceSPIE BioPhotonics Australasia
Country/TerritoryAustralia
CityAdelaide
Period16/10/1716/10/19

Keywords

  • acetone
  • biosniffer
  • breath
  • enzyme
  • fluotmetry
  • lipid metabolism
  • NADH

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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