Fusion and molecular aspects of liposomal nanocarriers incorporated with isoprenoids

Hidenori Nakagawa, Tsuyoshi Shiina, Masaki Sekino, Makoto Kotani, Shoogo Ueno

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The present study was conducted to investigate whether typical isoprenyl compounds (TICs) can control liposomal fusion reactions through changes in the physical properties of membranes. The fusion capabilities of TIC-incorporated liposomes were characterized by measuring the 13C spin-lattice relaxation times (13CT1) and the gel permeation chromatogram (GPC) patterns. The 13CT1 relaxivities of some of these TIC-liposomes were remarkably enhanced at 27°C. The highest 13CT1 value obtained was for the β-carotene-liposome, which ruptured, and was attributed to the highest membrane fusion reactivity. The other TIC-liposomes incorporated with α-tocopherol, canthaxanthin, or coenzyme Q10 also induced significant fusion and did not rupture in comparison with the β-carotene-liposome. These results show that the incorporations of TICs into lipid bilayers are useful to control liposomal nanocarriers for suitable membrane packing and advantageous phase separation, which could affect membrane-related processes.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalIEEE Transactions on Nanobioscience
Volume6
Issue number3
DOIs
Publication statusPublished - 2007 Sep
Externally publishedYes

Keywords

  • C-NMR
  • Biomembrane
  • Bionanotechnology
  • Fusion
  • Liposome
  • Relaxation

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science
  • Computer Science Applications
  • Electrical and Electronic Engineering

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