`Gate effect' of thin layer of molecularly-imprinted poly(methacrylic acid-co-ethyleneglycol dimethacrylate)

Yasuo Yoshimi, Ryo Ohdaira, Chiaki Iiyama, Kiyotaka Sakai

Research output: Contribution to journalArticle

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Abstract

Molecular imprinting is a new technology for the synthesis of polymers with antibody-like specificity, which are potentially useful in sensing or separation devices. Here, we report that a thin layer of molecularly-imprinted copolymer exhibits an increase in its diffusive permeability in the presence of its template. A thin layer of molecularly-imprinted poly(methacrylic acid-co-ethyleneglycol dimethacrylate) of theophylline was observed to form on the surface of electrically conductive indium-tin oxide (ITO) film. Cyclic voltammetry of ferrocyanide was performed using the copolymer-grafted ITO as a working electrode in the presence and absence of the template. The presence of the template was found to enhance the anodic current remarkably, which suggests that the diffusive permeability of the thin layer of the molecularly-imprinted polymer (MIP) is sensitive to the presence of its template molecule. This idea is supported by atomic force microscopy (AFM) in which the surface porosity of the layer of the MIP was observed to increased in the presence of its template. We conclude that the structure and diffusive permeability of a thin layer of molecularly-imprinted poly(methacrylic acid-co-ethyleneglycol dimethacrylate) enables this system to be used as a sensor for a given template.

LanguageEnglish
Pages49-53
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume73
Issue number1
DOIs
StatePublished - 2001 Feb 25

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Polymers
templates
Tin oxides
Indium
acids
Acids
Copolymers
permeability
Theophylline
Antibodies
indium oxides
tin oxides
Cyclic voltammetry
Oxide films
Atomic force microscopy
copolymers
polymers
Porosity
Electrodes
Molecules

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry
  • Electrical and Electronic Engineering

Cite this

`Gate effect' of thin layer of molecularly-imprinted poly(methacrylic acid-co-ethyleneglycol dimethacrylate). / Yoshimi, Yasuo; Ohdaira, Ryo; Iiyama, Chiaki; Sakai, Kiyotaka.

In: Sensors and Actuators, B: Chemical, Vol. 73, No. 1, 25.02.2001, p. 49-53.

Research output: Contribution to journalArticle

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