Hearing loss in humans drinking tube well water with high levels of iron in arsenic–polluted area

Tingchao He, Nobutaka Ohgami, Xiang Li, Ichiro Yajima, Reina Negishi-Oshino, Yoko Kato, Kyoko Ohgami, Huadong Xu, Nazmul Ahsan, Anwarul Azim Akhand, Masashi Kato

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Abstract

Well water for drinking with increased levels of iron in arsenic-polluted areas has been reported worldwide. Oral exposure to arsenic has been shown to be associated with hearing loss, while there is no evidence for an association between excessive exposure to iron and hearing loss in humans. In this study, we determined iron and arsenic levels in biological samples and hearing levels by pure tone audiometry (PTA) in subjects in a control area and an arsenic-polluted area in Bangladesh. The iron level in well water in the arsenic-polluted area was significantly higher than that in piped supply water in the control area. Subjects in the polluted area (n = 109), who had higher iron and arsenic levels in hair and toenails than those in subjects in the control area (n = 36), had an increased risk of hearing loss at 8 kHz and 12 kHz after adjustments for age, gender, smoking and BMI. Significant associations of the exposure group with hearing loss at 8 kHz and 12 kHz remained after further adjustment for arsenic levels in toenails and hair. Thus, this pilot study showed that excessive exposure to iron via drinking water is a potential risk for hearing loss in humans.

Original languageEnglish
Article number9028
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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    He, T., Ohgami, N., Li, X., Yajima, I., Negishi-Oshino, R., Kato, Y., Ohgami, K., Xu, H., Ahsan, N., Akhand, A. A., & Kato, M. (2019). Hearing loss in humans drinking tube well water with high levels of iron in arsenic–polluted area. Scientific Reports, 9(1), [9028]. https://doi.org/10.1038/s41598-019-45524-1