HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA

Ichiro Kumagai; Tsuyoshi Takahashi; Keita Hamasaki; Akihiko Ueno; Hisakazu Mihara

doi:10.1016/S0960-894X(01)00169-X

HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA

Ichiro Kumagai, Tsuyoshi Takahashi, Keita Hamasaki, Akihiko Ueno, Hisakazu Mihara

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

HIV Rev peptides conjugated with peptide nucleic acids (PNAs) were designed and synthesized to develop a designing approach for a novel RNA-binding molecule. The binding affinities of PNA-peptides with the Rev responsive element (RRE) RNA were determined by the competition assay using a rhodamine-labeled Rev. The peptide conjugated with an antisense PNA (TGCGC) bound RRE RNA more efficiently than the molecule without the PNA or the peptide sequence.

Original language	English
Pages (from-to)	1169-1172
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/S0960-894X(01)00169-X
Publication status	Published - 2001 May 7
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)00169-X

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AU - Kumagai, Ichiro

AU - Takahashi, Tsuyoshi

AU - Hamasaki, Keita

AU - Ueno, Akihiko

AU - Mihara, Hisakazu

PY - 2001/5/7

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AB - HIV Rev peptides conjugated with peptide nucleic acids (PNAs) were designed and synthesized to develop a designing approach for a novel RNA-binding molecule. The binding affinities of PNA-peptides with the Rev responsive element (RRE) RNA were determined by the competition assay using a rhodamine-labeled Rev. The peptide conjugated with an antisense PNA (TGCGC) bound RRE RNA more efficiently than the molecule without the PNA or the peptide sequence.

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HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA

Abstract

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