HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA

Ichiro Kumagai, Tsuyoshi Takahashi, Keita Hamasaki, Akihiko Ueno, Hisakazu Mihara

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

HIV Rev peptides conjugated with peptide nucleic acids (PNAs) were designed and synthesized to develop a designing approach for a novel RNA-binding molecule. The binding affinities of PNA-peptides with the Rev responsive element (RRE) RNA were determined by the competition assay using a rhodamine-labeled Rev. The peptide conjugated with an antisense PNA (TGCGC) bound RRE RNA more efficiently than the molecule without the PNA or the peptide sequence.

Original languageEnglish
Pages (from-to)1169-1172
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number9
DOIs
Publication statusPublished - 2001 May 7

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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