Abstract
γ-glutamyl transpeptidase (γ-GTP) is a membrane-bound enzyme which is known to play a crucial role in active transport of amino acids across membrane barriers. We prepared a monoclonal antibody recognizing specifically rat γ-GTP and investigated localization of the enzyme in the rat brain by immunohistochemistry with this antibody. The antigen was localized on the ependyma, epithelia of the choroid plexus and microvessels. More precise localization of γ-GTP was examined with immuno-electron microscopy. The antigen was recognized on the microvilli and cilia of the ependymal cells, microvilli of the choroid epithelial cells and luminal membranes of the vascular endothelial cells.
| Original language | English |
|---|---|
| Pages (from-to) | 597-601 |
| Number of pages | 5 |
| Journal | Tissue and Cell |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1998 Jan 1 |
| Externally published | Yes |
Keywords
- Choroid plexus
- Ependymal cell
- Immunohistochemistry
- Vascular endothelial cell
- γ-glutamyl transpeptidase
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
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Cite this
Ogawa, M., Shiozawa, M., Hiraoka, Y., Takeuchi, Y., & Aiso, S. (1998). Immunohistochemical study of localization of γ-glutamyl transpeptidase in the rat brain. Tissue and Cell, 30(6), 597-601. https://doi.org/10.1016/S0040-8166(98)80078-5