Immunological Study of the Colonic Mucosal Cell Destruction in Ulcerative Colitis

Role of ADCC Mechanism

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Lymphocyte cytotoxicity against rat colon epithelial cells which share the antigen-specificity with the human colon was examined in 30 cases of ulcerative colitis, using the 51Cr-release cytotoxicity assay. Lymphocyte cytotoxicity against rat colon cells was observed in the cases of ulcerative colitis, esp. in the active stage. This cytotoxicity was revealed to be mainly mediated by non-T cells. Antibody dependent cell-mediated cytotoxicity against the colon's cells was seen, using the sera of the patients and lymphocytes from healthy individual in the assay. The presence of anti-colon antibodies in these sera was demonstrated by analysis of the colon cells treated with the sera on a fluorescence activated cell sorter. All these results suggest that the mechanism of ADCC should play an important role in the destruction of the colonic cells in ulcerative colitis patients.

Original languageEnglish
Pages (from-to)2330-2336
Number of pages7
JournalNippon Shokakibyo Gakkai Zasshi
Volume78
Issue number12
DOIs
Publication statusPublished - 1981 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Immunological Study of the Colonic Mucosal Cell Destruction in Ulcerative Colitis : Role of ADCC Mechanism. / Aiso, Sadakazu.

In: Nippon Shokakibyo Gakkai Zasshi, Vol. 78, No. 12, 01.01.1981, p. 2330-2336.

Research output: Contribution to journalArticle

@article{bf7bc3177b49402e9bcee6b38719e789,
title = "Immunological Study of the Colonic Mucosal Cell Destruction in Ulcerative Colitis: Role of ADCC Mechanism",
abstract = "Lymphocyte cytotoxicity against rat colon epithelial cells which share the antigen-specificity with the human colon was examined in 30 cases of ulcerative colitis, using the 51Cr-release cytotoxicity assay. Lymphocyte cytotoxicity against rat colon cells was observed in the cases of ulcerative colitis, esp. in the active stage. This cytotoxicity was revealed to be mainly mediated by non-T cells. Antibody dependent cell-mediated cytotoxicity against the colon's cells was seen, using the sera of the patients and lymphocytes from healthy individual in the assay. The presence of anti-colon antibodies in these sera was demonstrated by analysis of the colon cells treated with the sera on a fluorescence activated cell sorter. All these results suggest that the mechanism of ADCC should play an important role in the destruction of the colonic cells in ulcerative colitis patients.",
author = "Sadakazu Aiso",
year = "1981",
month = "1",
day = "1",
doi = "10.11405/nisshoshi1964.78.2330",
language = "English",
volume = "78",
pages = "2330--2336",
journal = "Japanese Journal of Gastroenterology",
issn = "0446-6586",
publisher = "Japanese Society of Gastroenterology",
number = "12",

}

TY - JOUR

T1 - Immunological Study of the Colonic Mucosal Cell Destruction in Ulcerative Colitis

T2 - Role of ADCC Mechanism

AU - Aiso, Sadakazu

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Lymphocyte cytotoxicity against rat colon epithelial cells which share the antigen-specificity with the human colon was examined in 30 cases of ulcerative colitis, using the 51Cr-release cytotoxicity assay. Lymphocyte cytotoxicity against rat colon cells was observed in the cases of ulcerative colitis, esp. in the active stage. This cytotoxicity was revealed to be mainly mediated by non-T cells. Antibody dependent cell-mediated cytotoxicity against the colon's cells was seen, using the sera of the patients and lymphocytes from healthy individual in the assay. The presence of anti-colon antibodies in these sera was demonstrated by analysis of the colon cells treated with the sera on a fluorescence activated cell sorter. All these results suggest that the mechanism of ADCC should play an important role in the destruction of the colonic cells in ulcerative colitis patients.

AB - Lymphocyte cytotoxicity against rat colon epithelial cells which share the antigen-specificity with the human colon was examined in 30 cases of ulcerative colitis, using the 51Cr-release cytotoxicity assay. Lymphocyte cytotoxicity against rat colon cells was observed in the cases of ulcerative colitis, esp. in the active stage. This cytotoxicity was revealed to be mainly mediated by non-T cells. Antibody dependent cell-mediated cytotoxicity against the colon's cells was seen, using the sera of the patients and lymphocytes from healthy individual in the assay. The presence of anti-colon antibodies in these sera was demonstrated by analysis of the colon cells treated with the sera on a fluorescence activated cell sorter. All these results suggest that the mechanism of ADCC should play an important role in the destruction of the colonic cells in ulcerative colitis patients.

UR - http://www.scopus.com/inward/record.url?scp=0019758404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019758404&partnerID=8YFLogxK

U2 - 10.11405/nisshoshi1964.78.2330

DO - 10.11405/nisshoshi1964.78.2330

M3 - Article

VL - 78

SP - 2330

EP - 2336

JO - Japanese Journal of Gastroenterology

JF - Japanese Journal of Gastroenterology

SN - 0446-6586

IS - 12

ER -