Abstract
This research investigated the antimicrobial activities of unnatural nucleosides. We tested the MIC and MBC of 17 synthetic nucleoside analogues against 10 microbial strains. These nucleoside analogues were classified into four groups according to their structural characteristics. Inhibition was observed with compounds 1-1, 3-1, and 4-3. In particular, 5′- deoxythymidine (3-1) was most effective at 50 μ g/mL against Bacillus subtilis and Staphylococcus aureus. This analogue has had the hydroxyl group at the 5′ position replaced with a hydrogen atom. All compounds had weak effects against various species of mold. The MBC of 5′-deoxythymidine was 50 μg/mL in 0.5 h against S. aureus. These results showed that 5′-deoxythymidine had the most effective antimicrobial activity of the 17 different unnatural nucleosides. The inhibitory effect of 3-1 suggests that it may be useful as an antibacterial agent in medical situations.
| Original language | English |
|---|---|
| Pages (from-to) | 55-60 |
| Number of pages | 6 |
| Journal | Biocontrol Science |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 Jun |
Keywords
- Chemical structure
- MBC
- MIC
- Unnatural nucleoside
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Public Health, Environmental and Occupational Health
Cite this
Impact of unnatural nucleosides on the control of microbial growth. / Hatano, Akihiko; Nishimura, Makoto; Souta, Ikuo.
In: Biocontrol Science, Vol. 14, No. 2, 06.2009, p. 55-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of unnatural nucleosides on the control of microbial growth
AU - Hatano, Akihiko
AU - Nishimura, Makoto
AU - Souta, Ikuo
PY - 2009/6
Y1 - 2009/6
N2 - This research investigated the antimicrobial activities of unnatural nucleosides. We tested the MIC and MBC of 17 synthetic nucleoside analogues against 10 microbial strains. These nucleoside analogues were classified into four groups according to their structural characteristics. Inhibition was observed with compounds 1-1, 3-1, and 4-3. In particular, 5′- deoxythymidine (3-1) was most effective at 50 μ g/mL against Bacillus subtilis and Staphylococcus aureus. This analogue has had the hydroxyl group at the 5′ position replaced with a hydrogen atom. All compounds had weak effects against various species of mold. The MBC of 5′-deoxythymidine was 50 μg/mL in 0.5 h against S. aureus. These results showed that 5′-deoxythymidine had the most effective antimicrobial activity of the 17 different unnatural nucleosides. The inhibitory effect of 3-1 suggests that it may be useful as an antibacterial agent in medical situations.
AB - This research investigated the antimicrobial activities of unnatural nucleosides. We tested the MIC and MBC of 17 synthetic nucleoside analogues against 10 microbial strains. These nucleoside analogues were classified into four groups according to their structural characteristics. Inhibition was observed with compounds 1-1, 3-1, and 4-3. In particular, 5′- deoxythymidine (3-1) was most effective at 50 μ g/mL against Bacillus subtilis and Staphylococcus aureus. This analogue has had the hydroxyl group at the 5′ position replaced with a hydrogen atom. All compounds had weak effects against various species of mold. The MBC of 5′-deoxythymidine was 50 μg/mL in 0.5 h against S. aureus. These results showed that 5′-deoxythymidine had the most effective antimicrobial activity of the 17 different unnatural nucleosides. The inhibitory effect of 3-1 suggests that it may be useful as an antibacterial agent in medical situations.
KW - Chemical structure
KW - MBC
KW - MIC
KW - Unnatural nucleoside
UR - http://www.scopus.com/inward/record.url?scp=67649806930&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649806930&partnerID=8YFLogxK
U2 - 10.4265/bio.14.55
DO - 10.4265/bio.14.55
M3 - Article
C2 - 19579655
AN - SCOPUS:67649806930
VL - 14
SP - 55
EP - 60
JO - Biocontrol Science
JF - Biocontrol Science
SN - 1342-4815
IS - 2
ER -