Improvement of Photodynamic Activity by a Stable System Consisting of a C60Derivative and Photoantenna in Liposomes

Risako Shimada, Shodai Hino, Keita Yamana, Riku Kawasaki, Toshifumi Konishi, Atsushi Ikeda

Research output: Contribution to journalArticlepeer-review

Abstract

A dyad system comprising a lipid membrane-incorporated fullerene derivative with an N,N-dimethylpyrrodinium group (C60-1) and a photoantenna molecule (DiD) did not exhibit the high photodynamic activity expected based on its singlet oxygen generation ability. Comparison with a fullerene derivative with an amide substituent (C60-2) suggested the cause to be that some of the fullerene derivative had been released from the liposomes, partly disrupting the dyad system. The dyad system of C60-2 and DiD exhibited about twice the photodynamic activity toward HeLa cells as that of C60-1 and DiD, due to the suppression of the release of the fullerene derivative from the liposomes. The hydrophobicity/hydrophilicity balance of the substituent in fullerene derivatives was shown to be very important to obtain a dyad system in liposomes characterized by high photodynamic activity.

Original languageEnglish
Pages (from-to)641-647
Number of pages7
JournalACS Medicinal Chemistry Letters
Volume13
Issue number4
DOIs
Publication statusPublished - 2022 Apr 14

Keywords

  • Fullerenes
  • and photosensitizers
  • energy transfer
  • liposomes
  • photodynamic therapy

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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