In vivo evaluation of peripheral vascular resistance based on Poiseuille’s law

Kazuhiro Yokokawa, Saki Hamashima, Masahiro Shibata

Research output: Contribution to journalArticlepeer-review


To elucidate that Poiseuille's law can be applied in vivo microcirculation, we tried to analyze the total peripheral vascular resistance (R<inf>t</inf>) and single arteriolar resistance (R<inf>a</inf>) obtained from in vivo animal experiments. R<inf>t</inf> and R<inf>a</inf> values were quantified by measurements of systemic blood pressure (BP) , and by direct observation of microcirculation simultaneously. During L-NAME induced vasoconstriction, systemic BP significantly increased from 91 ± 8 mmHg to 114 ± 9 mmHg, while arterial diameter decreased from 137 ± 31 μm to 129 ± 30 μm (n = 14). The R<inf>t</inf> and R<inf>a</inf> values during vasoconstriction increased in 23.9 ± 10.4 % and 22.0 ± 9.9 %, respectively, which there were no significant differences. These result confirmed the Poiseuille's law is acceptable to apply for in vivo microcirculation.

Original languageEnglish
Pages (from-to)O-432-O-433
JournalTransactions of Japanese Society for Medical and Biological Engineering
Publication statusPublished - 2014 Aug 17


  • Microcirculation
  • Poiseuille law
  • Total peripheral vascular resistance

ASJC Scopus subject areas

  • Biomedical Engineering


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