Abstract
To elucidate that Poiseuille's law can be applied in vivo microcirculation, we tried to analyze the total peripheral vascular resistance (R<inf>t</inf>) and single arteriolar resistance (R<inf>a</inf>) obtained from in vivo animal experiments. R<inf>t</inf> and R<inf>a</inf> values were quantified by measurements of systemic blood pressure (BP) , and by direct observation of microcirculation simultaneously. During L-NAME induced vasoconstriction, systemic BP significantly increased from 91 ± 8 mmHg to 114 ± 9 mmHg, while arterial diameter decreased from 137 ± 31 μm to 129 ± 30 μm (n = 14). The R<inf>t</inf> and R<inf>a</inf> values during vasoconstriction increased in 23.9 ± 10.4 % and 22.0 ± 9.9 %, respectively, which there were no significant differences. These result confirmed the Poiseuille's law is acceptable to apply for in vivo microcirculation.
| Original language | English |
|---|---|
| Pages (from-to) | O-432-O-433 |
| Journal | Transactions of Japanese Society for Medical and Biological Engineering |
| Volume | 52 |
| DOIs | |
| Publication status | Published - 2014 Aug 17 |
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Keywords
- Microcirculation
- Poiseuille law
- Total peripheral vascular resistance
ASJC Scopus subject areas
- Biomedical Engineering
Cite this
In vivo evaluation of peripheral vascular resistance based on Poiseuille’s law. / Yokokawa, Kazuhiro; Hamashima, Saki; Shibata, Masahiro.
In: Transactions of Japanese Society for Medical and Biological Engineering, Vol. 52, 17.08.2014, p. O-432-O-433.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo evaluation of peripheral vascular resistance based on Poiseuille’s law
AU - Yokokawa, Kazuhiro
AU - Hamashima, Saki
AU - Shibata, Masahiro
PY - 2014/8/17
Y1 - 2014/8/17
N2 - To elucidate that Poiseuille's law can be applied in vivo microcirculation, we tried to analyze the total peripheral vascular resistance (Rt) and single arteriolar resistance (Ra) obtained from in vivo animal experiments. Rt and Ra values were quantified by measurements of systemic blood pressure (BP) , and by direct observation of microcirculation simultaneously. During L-NAME induced vasoconstriction, systemic BP significantly increased from 91 ± 8 mmHg to 114 ± 9 mmHg, while arterial diameter decreased from 137 ± 31 μm to 129 ± 30 μm (n = 14). The Rt and Ra values during vasoconstriction increased in 23.9 ± 10.4 % and 22.0 ± 9.9 %, respectively, which there were no significant differences. These result confirmed the Poiseuille's law is acceptable to apply for in vivo microcirculation.
AB - To elucidate that Poiseuille's law can be applied in vivo microcirculation, we tried to analyze the total peripheral vascular resistance (Rt) and single arteriolar resistance (Ra) obtained from in vivo animal experiments. Rt and Ra values were quantified by measurements of systemic blood pressure (BP) , and by direct observation of microcirculation simultaneously. During L-NAME induced vasoconstriction, systemic BP significantly increased from 91 ± 8 mmHg to 114 ± 9 mmHg, while arterial diameter decreased from 137 ± 31 μm to 129 ± 30 μm (n = 14). The Rt and Ra values during vasoconstriction increased in 23.9 ± 10.4 % and 22.0 ± 9.9 %, respectively, which there were no significant differences. These result confirmed the Poiseuille's law is acceptable to apply for in vivo microcirculation.
KW - Microcirculation
KW - Poiseuille law
KW - Total peripheral vascular resistance
UR - http://www.scopus.com/inward/record.url?scp=84939436791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939436791&partnerID=8YFLogxK
U2 - 10.11239/jsmbe.52.O-432
DO - 10.11239/jsmbe.52.O-432
M3 - Article
VL - 52
SP - O-432-O-433
JO - BME = Bio medical engineering / henshu, Nihon ME Gakkai
JF - BME = Bio medical engineering / henshu, Nihon ME Gakkai
SN - 1347-443X
ER -