To elucidate that Poiseuille's law can be applied in vivo microcirculation, we tried to analyze the total peripheral vascular resistance (R<inf>t</inf>) and single arteriolar resistance (R<inf>a</inf>) obtained from in vivo animal experiments. R<inf>t</inf> and R<inf>a</inf> values were quantified by measurements of systemic blood pressure (BP) , and by direct observation of microcirculation simultaneously. During L-NAME induced vasoconstriction, systemic BP significantly increased from 91 ± 8 mmHg to 114 ± 9 mmHg, while arterial diameter decreased from 137 ± 31 μm to 129 ± 30 μm (n = 14). The R<inf>t</inf> and R<inf>a</inf> values during vasoconstriction increased in 23.9 ± 10.4 % and 22.0 ± 9.9 %, respectively, which there were no significant differences. These result confirmed the Poiseuille's law is acceptable to apply for in vivo microcirculation.
|Journal||Transactions of Japanese Society for Medical and Biological Engineering|
|Publication status||Published - 2014 Aug 17|
- Poiseuille law
- Total peripheral vascular resistance
ASJC Scopus subject areas
- Biomedical Engineering