Increased F2-isoprostane levels in the rat brain and plasma caused by oxidative stress and aging, and inhibitory effect of vitamin E

Tomoko Nishio, Ryota Miyadera, Ryuta Sakai, Kouichi Abe, Hideko Kanazawa, Koji Fukui, Shiro Urano

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

To determine whether lipid peroxidation induced by reactive oxygen species (ROS) is a causal factor of neurodegeneration during brain aging, we investigated whether F2-isoprostanes, non-cyclooxygenase-derived prostanoids, are formed in the rat brain and plasma by hyperoxia as oxidative stress, and whether their formation is associated with vitamin E status in vivo in association with changes that occur during brain aging. Young rats subjected to hyperoxia for 48 h revealed a marked increase in the levels of F2-isoprostanes in the brain, but not in plasma. A similar increase in F2-isoprostane level was observed in aged rats kept in normal atmosphere. Vitamin E supplementation to young rats markedly inhibited F2-isoprostane formation even after hyperoxia. In contrast, vitamin E-deficient young rats kept in normal atmosphere showed a significant increase in F2-isoprostane level in the brain. These findings indicate that F2-isoprostane formation in the brain has important implications in the etiology of neurodegenerative diseases including Alzheimer's disease during aging, and that the analysis of F2-isoprostane level in plasma does not always reflect neuronal damage cause by oxidative stress. Vitamin E may protect neuronal damage in the brain caused by oxidative stress experienced for a long period during aging.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume38
Issue number3
DOIs
Publication statusPublished - 2006 May
Externally publishedYes

Fingerprint

F2-Isoprostanes
Oxidative stress
Vitamin E
vitamin E
Rats
Brain
oxidative stress
Aging of materials
hyperoxia
brain
Plasmas
rats
brain damage
Neurodegenerative diseases
neurodegenerative diseases
Alzheimer disease
prostaglandins
etiology
reactive oxygen species
lipid peroxidation

Keywords

  • Brain
  • F2-isoprostane
  • Neurodegeneration
  • Oxidative stress
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Increased F2-isoprostane levels in the rat brain and plasma caused by oxidative stress and aging, and inhibitory effect of vitamin E. / Nishio, Tomoko; Miyadera, Ryota; Sakai, Ryuta; Abe, Kouichi; Kanazawa, Hideko; Fukui, Koji; Urano, Shiro.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 38, No. 3, 05.2006, p. 161-166.

Research output: Contribution to journalArticle

Nishio, Tomoko ; Miyadera, Ryota ; Sakai, Ryuta ; Abe, Kouichi ; Kanazawa, Hideko ; Fukui, Koji ; Urano, Shiro. / Increased F2-isoprostane levels in the rat brain and plasma caused by oxidative stress and aging, and inhibitory effect of vitamin E. In: Journal of Clinical Biochemistry and Nutrition. 2006 ; Vol. 38, No. 3. pp. 161-166.
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