Inhibitory effects on microbial growth using the derivatives of benzyl phenyl sulfide

Akihiko Hatano, Munehiro Okada, Kei Shimazaki, Sanae Uehara, Yuta Ishikawa, Arata Matsumoto, Yudai Fujita, Makoto Nishimura

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We investigated the antimicrobial activities of twelve derivatives of benzyl phenyl sulfide by using Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values against 10 microbial strains. These derivatives of benzyl phenyl sulfides were synthesized by means of the nucleophilic coupling reaction at our laboratory. MIC testing revealed that all synthetic derivatives of benzyl and 4-methoxybenzyl phenyl sulfides had no effect against the tested microbial strains. However, the compounds of 4-nitrobenzyl phenyl sulfide showed antimicrobial activity against many of the tested strains. Above all, 4-nitrobenzyl 4-chlorophenyl sulfide 11 exhibited the strongest and widest ranging inhibitory effects among the twelve synthetic compounds. We researched the antimicrobial activities of the coupling materials of sulfide. As a result, it was considered important for the expression of antimicrobial activities that the sulfide had a 4-nitrobenzyl group and 4-chlorophenyl group in the same molecule as in the case of benzyl phenyl sulfide.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalBiocontrol Science
Issue number2
Publication statusPublished - 2011 Jun 10


  • Benzyl phenyl sulfide
  • Chemical structure
  • Halogen group
  • MBC
  • MIC

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Public Health, Environmental and Occupational Health


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