Integration of decellularized ligament and artificial material through recellularization for periodontal reconstruction

Naoko Nakamura, Hiroki Harukaze, Ryota Ohira, Masahiro Yamada, Toshiya Fujisato, Tsuyoshi Kimura, Akio Kishida

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dental implant treatment is a major treatment for lack of teeth. Dental implant directly binds to bone of jaw. Our teeth are normally supported by periodontal membranes which exist between teeth and mandible bone and consist of collagen fibers. The lack of the periodontal membrane is one of problems of dental implant treatment because periodontal membrane acts as many functions, such as supporting teeth, feeling, and preventing form the infection. In order to overcome this problem, we have tried preparing the unit of mandible bone, periodontal membrane and artificial tooth. In previous research, the mandible bone and periodontal membrane were prepared by decellularization method. And artificial tooth was prepared by 3-D printer and their surface was modified by calcification method. These were implanted together in rat renal capsule, and then the rat host cells infiltrated the periodontal membrane and construct the extracellular matrix between decellularized mandible bone and artificial tooth. It was suggested the collagen fibers of decellularized periodontal membrane was combined with the surface of artificial tooth. In this study, we targeted to reveal the combining of decellularized ligament and artificial material, because it is most important for periodontal reconstruction. We here developed the simple model which consists of ligament extracellular matrix sheet and artificial material plate. And we investigated the combining of collagen fibers and material surface by implanting them in vivo.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - 2019 Jan 1
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 2019 Apr 32019 Apr 6

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period19/4/319/4/6

Fingerprint

Ligaments
Membranes
Bone
Dental prostheses
Collagen
Fibers
Rats
3D printers
Capsules

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Nakamura, N., Harukaze, H., Ohira, R., Yamada, M., Fujisato, T., Kimura, T., & Kishida, A. (2019). Integration of decellularized ligament and artificial material through recellularization for periodontal reconstruction. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Integration of decellularized ligament and artificial material through recellularization for periodontal reconstruction. / Nakamura, Naoko; Harukaze, Hiroki; Ohira, Ryota; Yamada, Masahiro; Fujisato, Toshiya; Kimura, Tsuyoshi; Kishida, Akio.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nakamura, N, Harukaze, H, Ohira, R, Yamada, M, Fujisato, T, Kimura, T & Kishida, A 2019, Integration of decellularized ligament and artificial material through recellularization for periodontal reconstruction. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 19/4/3.
Nakamura N, Harukaze H, Ohira R, Yamada M, Fujisato T, Kimura T et al. Integration of decellularized ligament and artificial material through recellularization for periodontal reconstruction. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Nakamura, Naoko ; Harukaze, Hiroki ; Ohira, Ryota ; Yamada, Masahiro ; Fujisato, Toshiya ; Kimura, Tsuyoshi ; Kishida, Akio. / Integration of decellularized ligament and artificial material through recellularization for periodontal reconstruction. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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