Intervendor variability of carotid intima–media thickness measurement: validation study using newly developed ultrasound phantom

Tomoko Ishizu, Hirotoshi Hamaguchi, Naotaka Nitta, Yoshihiro Seo, Hiroshi Matsuo, Tsuyoshi Shiina

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Ultrasonography-derived carotid artery intima–media thickness (IMT) has been established as an early atherosclerotic imaging biomarker. The IMT reference value of a healthy person is approximately 0.1 × (every 10 years of age) + 0.2 (mm); accordingly, it requires an accuracy of at least 0.1 mm. However, one concern of IMT measurement is intervendor variability. In this study, we aimed to verify the intervendor variability using an IMT phantom. Methods: An improved IMT phantom was developed, and it was possible to analyze the IMT by software for all vendors. Results: With the vendor-specific software, the maximum difference between the devices was 0.08 mm, and the difference in quartile range was 0.06 mm. On the other hand, with the vendor-independent offline software, the maximum difference between the devices was 0.16 mm, and the quartile range of variation was 0.06 mm. Conclusion: The intervendor variability assessed using our IMT phantom was less than 0.10 mm, and the on-board vendor-specific software was shown to reduce the difference between the devices significantly compared with the vendor-independent offline software. To further improve the vender difference, adjustment by means of vendor-specific software based on a standardized IMT phantom is warranted.

Original languageEnglish
Pages (from-to)155-165
Number of pages11
JournalJournal of Medical Ultrasonics
Volume47
Issue number2
DOIs
Publication statusPublished - 2020 Apr 1
Externally publishedYes

Keywords

  • Intervendor variability
  • Intima–media thickness
  • Quality control

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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