TY - JOUR
T1 - Intervendor variability of carotid intima–media thickness measurement
T2 - validation study using newly developed ultrasound phantom
AU - Ishizu, Tomoko
AU - Hamaguchi, Hirotoshi
AU - Nitta, Naotaka
AU - Seo, Yoshihiro
AU - Matsuo, Hiroshi
AU - Shiina, Tsuyoshi
N1 - Funding Information:
The authors thank all industry partners—Fuji-Film, Fukuda Denshi, GE, Hitachi, Konica Minolta, Philips, Siemens, and Canon—for their active contribution to this project. Their support has been essential to its realization. This research was conducted by the research and development team of the Japan Society of Ultrasonics in Medicine, Heisei 28 and 29 “Research on accuracy control and diagnostic standardization of carotid intima–media thickness measurement”.
Publisher Copyright:
© 2020, The Japan Society of Ultrasonics in Medicine.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Purpose: Ultrasonography-derived carotid artery intima–media thickness (IMT) has been established as an early atherosclerotic imaging biomarker. The IMT reference value of a healthy person is approximately 0.1 × (every 10 years of age) + 0.2 (mm); accordingly, it requires an accuracy of at least 0.1 mm. However, one concern of IMT measurement is intervendor variability. In this study, we aimed to verify the intervendor variability using an IMT phantom. Methods: An improved IMT phantom was developed, and it was possible to analyze the IMT by software for all vendors. Results: With the vendor-specific software, the maximum difference between the devices was 0.08 mm, and the difference in quartile range was 0.06 mm. On the other hand, with the vendor-independent offline software, the maximum difference between the devices was 0.16 mm, and the quartile range of variation was 0.06 mm. Conclusion: The intervendor variability assessed using our IMT phantom was less than 0.10 mm, and the on-board vendor-specific software was shown to reduce the difference between the devices significantly compared with the vendor-independent offline software. To further improve the vender difference, adjustment by means of vendor-specific software based on a standardized IMT phantom is warranted.
AB - Purpose: Ultrasonography-derived carotid artery intima–media thickness (IMT) has been established as an early atherosclerotic imaging biomarker. The IMT reference value of a healthy person is approximately 0.1 × (every 10 years of age) + 0.2 (mm); accordingly, it requires an accuracy of at least 0.1 mm. However, one concern of IMT measurement is intervendor variability. In this study, we aimed to verify the intervendor variability using an IMT phantom. Methods: An improved IMT phantom was developed, and it was possible to analyze the IMT by software for all vendors. Results: With the vendor-specific software, the maximum difference between the devices was 0.08 mm, and the difference in quartile range was 0.06 mm. On the other hand, with the vendor-independent offline software, the maximum difference between the devices was 0.16 mm, and the quartile range of variation was 0.06 mm. Conclusion: The intervendor variability assessed using our IMT phantom was less than 0.10 mm, and the on-board vendor-specific software was shown to reduce the difference between the devices significantly compared with the vendor-independent offline software. To further improve the vender difference, adjustment by means of vendor-specific software based on a standardized IMT phantom is warranted.
KW - Intervendor variability
KW - Intima–media thickness
KW - Quality control
UR - http://www.scopus.com/inward/record.url?scp=85079645348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079645348&partnerID=8YFLogxK
U2 - 10.1007/s10396-019-00995-7
DO - 10.1007/s10396-019-00995-7
M3 - Article
C2 - 32067178
AN - SCOPUS:85079645348
VL - 47
SP - 155
EP - 165
JO - Japanese Journal of Medical Ultrasonics
JF - Japanese Journal of Medical Ultrasonics
SN - 1346-4523
IS - 2
ER -