Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N

Osamu Kitagawa, Takashi Suzuki, Tadashi Inoue, Takeo Taguchi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In the presence of TiCl4 and Et3N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.

Original languageEnglish
Pages (from-to)7357-7360
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number40
Publication statusPublished - 1998 Oct 1
Externally publishedYes

Fingerprint

Alkynes
Derivatives
titanium tetrachloride

Keywords

  • Alkynes
  • Cyclization
  • Cyclopentanes
  • Titanium and compounds

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N. / Kitagawa, Osamu; Suzuki, Takashi; Inoue, Tadashi; Taguchi, Takeo.

In: Tetrahedron Letters, Vol. 39, No. 40, 01.10.1998, p. 7357-7360.

Research output: Contribution to journalArticle

Kitagawa, Osamu ; Suzuki, Takashi ; Inoue, Tadashi ; Taguchi, Takeo. / Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 40. pp. 7357-7360.
@article{c6c579e5b7d544b9993d122891799f42,
title = "Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N",
abstract = "In the presence of TiCl4 and Et3N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.",
keywords = "Alkynes, Cyclization, Cyclopentanes, Titanium and compounds",
author = "Osamu Kitagawa and Takashi Suzuki and Tadashi Inoue and Takeo Taguchi",
year = "1998",
month = "10",
day = "1",
language = "English",
volume = "39",
pages = "7357--7360",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "40",

}

TY - JOUR

T1 - Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N

AU - Kitagawa, Osamu

AU - Suzuki, Takashi

AU - Inoue, Tadashi

AU - Taguchi, Takeo

PY - 1998/10/1

Y1 - 1998/10/1

N2 - In the presence of TiCl4 and Et3N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.

AB - In the presence of TiCl4 and Et3N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.

KW - Alkynes

KW - Cyclization

KW - Cyclopentanes

KW - Titanium and compounds

UR - http://www.scopus.com/inward/record.url?scp=0032190772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032190772&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032190772

VL - 39

SP - 7357

EP - 7360

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 40

ER -