Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N

Osamu Kitagawa; Takashi Suzuki; Tadashi Inoue; Takeo Taguchi

doi:10.1016/S0040-4039(98)01579-2

Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl₄-Et₃N

Osamu Kitagawa, Takashi Suzuki, Tadashi Inoue, Takeo Taguchi

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

In the presence of TiCl₄ and Et₃N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.

Original language	English
Pages (from-to)	7357-7360
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	40
DOIs	https://doi.org/10.1016/S0040-4039(98)01579-2
Publication status	Published - 1998 Oct 1
Externally published	Yes

Keywords

Alkynes
Cyclization
Cyclopentanes
Titanium and compounds

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)01579-2

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title = "Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N",

abstract = "In the presence of TiCl4 and Et3N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.",

keywords = "Alkynes, Cyclization, Cyclopentanes, Titanium and compounds",

author = "Osamu Kitagawa and Takashi Suzuki and Tadashi Inoue and Takeo Taguchi",

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AU - Kitagawa, Osamu

AU - Suzuki, Takashi

AU - Inoue, Tadashi

AU - Taguchi, Takeo

PY - 1998/10/1

Y1 - 1998/10/1

N2 - In the presence of TiCl4 and Et3N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.

AB - In the presence of TiCl4 and Et3N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.

KW - Alkynes

KW - Cyclization

KW - Cyclopentanes

KW - Titanium and compounds

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