Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N

Osamu Kitagawa, Takashi Suzuki, Tadashi Inoue, Takeo Taguchi

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

In the presence of TiCl4 and Et3N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.

Original languageEnglish
Pages (from-to)7357-7360
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number40
DOIs
Publication statusPublished - 1998 Oct 1
Externally publishedYes

Keywords

  • Alkynes
  • Cyclization
  • Cyclopentanes
  • Titanium and compounds

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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