Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N

Osamu Kitagawa, Takashi Suzuki, Tadashi Inoue, Takeo Taguchi

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

In the presence of TiCl4 and Et3N, intramolecular carbotitanation reaction of active methine compounds having an unactivated 4-alkynyl group proceeds in a highly cis-selective manner to give methylenecyclopentane derivatives in good yields.

Original languageEnglish
Pages (from-to)7357-7360
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number40
Publication statusPublished - 1998 Oct 1
Externally publishedYes

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Alkynes
Derivatives
titanium tetrachloride

Keywords

  • Alkynes
  • Cyclization
  • Cyclopentanes
  • Titanium and compounds

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N. / Kitagawa, Osamu; Suzuki, Takashi; Inoue, Tadashi; Taguchi, Takeo.

In: Tetrahedron Letters, Vol. 39, No. 40, 01.10.1998, p. 7357-7360.

Research output: Contribution to journal › Article

Kitagawa, O, Suzuki, T, Inoue, T & Taguchi, T 1998, 'Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N', Tetrahedron Letters, vol. 39, no. 40, pp. 7357-7360.
Kitagawa O, Suzuki T, Inoue T, Taguchi T. Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N. Tetrahedron Letters. 1998 Oct 1;39(40):7357-7360.
Kitagawa, Osamu ; Suzuki, Takashi ; Inoue, Tadashi ; Taguchi, Takeo. / Intramolecular carbotitanation reaction of active methine compounds having an unactivated alkyne mediated by TiCl4-Et3N. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 40. pp. 7357-7360.
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