Lanthanide complex-oligo-DNA hybrid for sequence-selective hydrolysis of RNA

Kazunari Matsumura, Masayuki Endo, Makoto Komiyama

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Abstract

Iminodiacetate complexes of lanthanide(III) ions (lutetium, europium, thulium and lanthanum), attached to the 5′-end of a 15-mer DNA, hydrolyse a 39-mer RNA selectively at the 3′-side of its 15-mer sequence, which is complementary with the DNA.

Original languageEnglish
Pages (from-to)2019-2020
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number17
DOIs
Publication statusPublished - 1994 Dec 1

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ASJC Scopus subject areas

  • Molecular Medicine

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